Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

Samuel K. Lai, Ying Ying Wang, Justin S Hanes

Research output: Contribution to journalArticle

Abstract

Mucus is a viscoelastic and adhesive gel that protects the lung airways, gastrointestinal (GI) tract, vagina, eye and other mucosal surfaces. Most foreign particulates, including conventional particle-based drug delivery systems, are efficiently trapped in human mucus layers by steric obstruction and/or adhesion. Trapped particles are typically removed from the mucosal tissue within seconds to a few hours depending on anatomical location, thereby strongly limiting the duration of sustained drug delivery locally. A number of debilitating diseases could be treated more effectively and with fewer side effects if drugs and genes could be more efficiently delivered to the underlying mucosal tissues in a controlled manner. This review first describes the tenacious mucus barrier properties that have precluded the efficient penetration of therapeutic particles. It then reviews the design and development of new mucus-penetrating particles that may avoid rapid mucus clearance mechanisms, and thereby provide targeted or sustained drug delivery for localized therapies in mucosal tissues.

Original languageEnglish (US)
Pages (from-to)158-171
Number of pages14
JournalAdvanced Drug Delivery Reviews
Volume61
Issue number2
DOIs
StatePublished - Feb 27 2009

Fingerprint

Mucus
Nanoparticles
Mucous Membrane
Pharmaceutical Preparations
Genes
Vagina
Drug Delivery Systems
Drug-Related Side Effects and Adverse Reactions
Adhesives
Gastrointestinal Tract
Gels
Lung
Therapeutics

Keywords

  • Mucus
  • Mucus barrier properties
  • Mucus-penetrating particles
  • Therapeutic particles

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. / Lai, Samuel K.; Wang, Ying Ying; Hanes, Justin S.

In: Advanced Drug Delivery Reviews, Vol. 61, No. 2, 27.02.2009, p. 158-171.

Research output: Contribution to journalArticle

@article{be9e55c5203e4f629f3d2f0a26a3c8bf,
title = "Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues",
abstract = "Mucus is a viscoelastic and adhesive gel that protects the lung airways, gastrointestinal (GI) tract, vagina, eye and other mucosal surfaces. Most foreign particulates, including conventional particle-based drug delivery systems, are efficiently trapped in human mucus layers by steric obstruction and/or adhesion. Trapped particles are typically removed from the mucosal tissue within seconds to a few hours depending on anatomical location, thereby strongly limiting the duration of sustained drug delivery locally. A number of debilitating diseases could be treated more effectively and with fewer side effects if drugs and genes could be more efficiently delivered to the underlying mucosal tissues in a controlled manner. This review first describes the tenacious mucus barrier properties that have precluded the efficient penetration of therapeutic particles. It then reviews the design and development of new mucus-penetrating particles that may avoid rapid mucus clearance mechanisms, and thereby provide targeted or sustained drug delivery for localized therapies in mucosal tissues.",
keywords = "Mucus, Mucus barrier properties, Mucus-penetrating particles, Therapeutic particles",
author = "Lai, {Samuel K.} and Wang, {Ying Ying} and Hanes, {Justin S}",
year = "2009",
month = "2",
day = "27",
doi = "10.1016/j.addr.2008.11.002",
language = "English (US)",
volume = "61",
pages = "158--171",
journal = "Advanced Drug Delivery Reviews",
issn = "0169-409X",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

AU - Lai, Samuel K.

AU - Wang, Ying Ying

AU - Hanes, Justin S

PY - 2009/2/27

Y1 - 2009/2/27

N2 - Mucus is a viscoelastic and adhesive gel that protects the lung airways, gastrointestinal (GI) tract, vagina, eye and other mucosal surfaces. Most foreign particulates, including conventional particle-based drug delivery systems, are efficiently trapped in human mucus layers by steric obstruction and/or adhesion. Trapped particles are typically removed from the mucosal tissue within seconds to a few hours depending on anatomical location, thereby strongly limiting the duration of sustained drug delivery locally. A number of debilitating diseases could be treated more effectively and with fewer side effects if drugs and genes could be more efficiently delivered to the underlying mucosal tissues in a controlled manner. This review first describes the tenacious mucus barrier properties that have precluded the efficient penetration of therapeutic particles. It then reviews the design and development of new mucus-penetrating particles that may avoid rapid mucus clearance mechanisms, and thereby provide targeted or sustained drug delivery for localized therapies in mucosal tissues.

AB - Mucus is a viscoelastic and adhesive gel that protects the lung airways, gastrointestinal (GI) tract, vagina, eye and other mucosal surfaces. Most foreign particulates, including conventional particle-based drug delivery systems, are efficiently trapped in human mucus layers by steric obstruction and/or adhesion. Trapped particles are typically removed from the mucosal tissue within seconds to a few hours depending on anatomical location, thereby strongly limiting the duration of sustained drug delivery locally. A number of debilitating diseases could be treated more effectively and with fewer side effects if drugs and genes could be more efficiently delivered to the underlying mucosal tissues in a controlled manner. This review first describes the tenacious mucus barrier properties that have precluded the efficient penetration of therapeutic particles. It then reviews the design and development of new mucus-penetrating particles that may avoid rapid mucus clearance mechanisms, and thereby provide targeted or sustained drug delivery for localized therapies in mucosal tissues.

KW - Mucus

KW - Mucus barrier properties

KW - Mucus-penetrating particles

KW - Therapeutic particles

UR - http://www.scopus.com/inward/record.url?scp=60149111908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60149111908&partnerID=8YFLogxK

U2 - 10.1016/j.addr.2008.11.002

DO - 10.1016/j.addr.2008.11.002

M3 - Article

VL - 61

SP - 158

EP - 171

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

IS - 2

ER -