Mucus penetrating nanoparticles: Biophysical tool and method of drug and gene delivery

Laura M. Ensign, Craig Schneider, Jung Soo Suk, Richard Cone, Justin Hanes

Research output: Contribution to journalArticle

Abstract

A method that could provide more uniform and longer-lasting drug and gene delivery to mucosal surfaces holds the potential to greatly improve the effectiveness of prophylactic and therapeutic approaches for numerous diseases and conditions, including sexually transmitted infections, cystic fi brosis, chronic rhinosinusitis, infl ammatory bowel disease, and glaucoma to name a few. However, the body's natural defenses, including adhesive, rapidly cleared mucus linings coating nearly all entry points to the body not covered by skin, has limited the effectiveness of drug and gene delivery by nanoscale delivery systems. This article discusses the recent development of the "mucuspenetrating particle" or "MPP" nanotechnology, and how it has been used to both enhance understanding of the nanoscale barrier properties of human mucus secretions, and to achieve more uniform and longer-lasting drug delivery to mucosal tissues following topical administration. Drug loaded MPPs possess non-adhesive coatings that allow them to rapidly penetrate mucus layers through openings in the mucus mesh at rates nearly as fast as they would penetrate pure water. Critically, MPPs allow enhanced drug and gene delivery to mucosal tissues without diminishing the protective function of mucus. Recent progress in the development of MPPs as a biophysical tool to probe the length-scale dependent rheological properties of mucosal secretions and as a method for drug and gene delivery is highlighted.

Original languageEnglish (US)
Pages (from-to)3887-3894
Number of pages8
JournalAdvanced Materials
Volume24
Issue number28
DOIs
StatePublished - Jul 24 2012

Keywords

  • gene therapy
  • mucosal drug delivery
  • mucus microstructure
  • nanoparticles
  • nanotechnology

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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