Mucosal IFN-γ Gene Transfer Inhibits Pulmonary Allergic Responses in Mice

Xiu Min Li, Rajesh K. Chopra, Teh Ying Chou, Brian H. Schofield, Marsha Wills-Karp, Shau Ku Huang

Research output: Contribution to journalArticle

Abstract

Th2 cytokines are associated with the airway inflammation and hyperreactivity in allergic asthma and are potential targets for developing novel therapies. The efficacy of a mucosal cytokine-gene transfer approach was examined in a mouse model for allergic asthma. We showed first that mucosal IFN-γ gene transfer results in a significant expression of IFN-γ in the pulmonary epithelium. Significantly, this approach inhibits both Ag- and Th2-cell-induced pulmonary eosinophilia and airway hyperreactivity. These findings suggest that mucosal IFN-γ gene transfer is effective in modulating pulmonary allergic responses and provides a basis for developing a novel therapeutic approach.

Original languageEnglish (US)
Pages (from-to)3216-3219
Number of pages4
JournalJournal of Immunology
Volume157
Issue number8
StatePublished - Oct 15 1996

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Lung
Asthma
Pulmonary Eosinophilia
Cytokines
Genes
Th2 Cells
Epithelium
Inflammation
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

Li, X. M., Chopra, R. K., Chou, T. Y., Schofield, B. H., Wills-Karp, M., & Huang, S. K. (1996). Mucosal IFN-γ Gene Transfer Inhibits Pulmonary Allergic Responses in Mice. Journal of Immunology, 157(8), 3216-3219.

Mucosal IFN-γ Gene Transfer Inhibits Pulmonary Allergic Responses in Mice. / Li, Xiu Min; Chopra, Rajesh K.; Chou, Teh Ying; Schofield, Brian H.; Wills-Karp, Marsha; Huang, Shau Ku.

In: Journal of Immunology, Vol. 157, No. 8, 15.10.1996, p. 3216-3219.

Research output: Contribution to journalArticle

Li, XM, Chopra, RK, Chou, TY, Schofield, BH, Wills-Karp, M & Huang, SK 1996, 'Mucosal IFN-γ Gene Transfer Inhibits Pulmonary Allergic Responses in Mice', Journal of Immunology, vol. 157, no. 8, pp. 3216-3219.
Li XM, Chopra RK, Chou TY, Schofield BH, Wills-Karp M, Huang SK. Mucosal IFN-γ Gene Transfer Inhibits Pulmonary Allergic Responses in Mice. Journal of Immunology. 1996 Oct 15;157(8):3216-3219.
Li, Xiu Min ; Chopra, Rajesh K. ; Chou, Teh Ying ; Schofield, Brian H. ; Wills-Karp, Marsha ; Huang, Shau Ku. / Mucosal IFN-γ Gene Transfer Inhibits Pulmonary Allergic Responses in Mice. In: Journal of Immunology. 1996 ; Vol. 157, No. 8. pp. 3216-3219.
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