Mucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial

Charlene S. Dezzutti, Barbra A. Richardson, Jeanne M. Marrazzo, Jessica Tugetman, Gita Ramjee, Taha E Taha, Zvavahera M. Chirenje, Salim S. Abdool Karim, Sharon L. Hillier, Betsy C. Herold

Research output: Contribution to journalArticle

Abstract

The mucosal environment may impact the risk for human immunodeficiency virus type 1 (HIV-1) acquisition. Immune mediators were measured in vaginal fluid collected from HPTN 035 participants who acquired HIV-1 and from those who remained HIV-1 negative (controls). Mediator concentrations were similar in samples obtained before as compared to after HIV-1 acquisition in the 8 seroconverters. Compared with controls, seroconverters were more likely to have detectable levels of HD-2 (odds ratio [OR], 2.39; P =. 005) and greater Escherichia coli bactericidal activity (OR, 1.22; P =. 01) prior to seroconversion. E. coli bactericidal activity remained significant in a multivariable analysis (P =. 02) and may be a biomarker for HIV-1 acquisition.

Original languageEnglish (US)
Pages (from-to)1931-1935
Number of pages5
JournalJournal of Infectious Diseases
Volume206
Issue number12
DOIs
StatePublished - Dec 15 2012

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HIV-1
Escherichia coli
Odds Ratio
Biomarkers
Seroconversion

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Mucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial. / Dezzutti, Charlene S.; Richardson, Barbra A.; Marrazzo, Jeanne M.; Tugetman, Jessica; Ramjee, Gita; Taha, Taha E; Chirenje, Zvavahera M.; Abdool Karim, Salim S.; Hillier, Sharon L.; Herold, Betsy C.

In: Journal of Infectious Diseases, Vol. 206, No. 12, 15.12.2012, p. 1931-1935.

Research output: Contribution to journalArticle

Dezzutti, CS, Richardson, BA, Marrazzo, JM, Tugetman, J, Ramjee, G, Taha, TE, Chirenje, ZM, Abdool Karim, SS, Hillier, SL & Herold, BC 2012, 'Mucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial', Journal of Infectious Diseases, vol. 206, no. 12, pp. 1931-1935. https://doi.org/10.1093/infdis/jis555
Dezzutti, Charlene S. ; Richardson, Barbra A. ; Marrazzo, Jeanne M. ; Tugetman, Jessica ; Ramjee, Gita ; Taha, Taha E ; Chirenje, Zvavahera M. ; Abdool Karim, Salim S. ; Hillier, Sharon L. ; Herold, Betsy C. / Mucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial. In: Journal of Infectious Diseases. 2012 ; Vol. 206, No. 12. pp. 1931-1935.
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