Mucosal antitoxic and antibacterial immunity after Cholera disease and after immunization with a combined B subunit-whole cell vaccine

Ann Mari Svennerholm, Marianne Jertborn, Leif Gothefors, A. M.M.M. Karim, David A. Sack, Jan Holmgren

Research output: Contribution to journalArticlepeer-review

Abstract

Mucosal and systemic immune responses to a new oral cholera vaccine, consisting of the B subunit plus killed vibrios, were studied in Bangladeshi volunteers and compared with those to clinical cholera. A single peroral dose of vaccine induced a local IgA antitoxin response in intestinal-lavage fluid of seven of eight vaccinees; the response closely mimicked that of patients convalescing from cholera, and evidence of the induction of local immunologic memory was found as well. Two peroral doses were needed for stimulation of an intestinal IgA immune response to the lipopolysaccharide of Vibrio cholerae that was comparable to the response obtained after clinical cholera. This response to peroral immunization was considerably stronger than that to parenteral vaccination, although the intramuscular route gave rise to the strongest IgG antitoxin and antilipolysaccharide responses in serum. The results suggest that B subunit-whole cell vaccine, when given in at least two oral doses, may be a good candidate for use in cholera prophylaxis.

Original languageEnglish (US)
Pages (from-to)884-893
Number of pages10
JournalJournal of Infectious Diseases
Volume149
Issue number6
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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