Mucosal and systemic immunity to Campylobacter jejuni in rabbits after gastric inoculation

D. H. Burr, M. B. Caldwell, Louis Bourgeois, H. R. Morgan, R. Wistar, R. I. Walker

Research output: Contribution to journalArticle

Abstract

The mucosal and systemic immune responses to Campylobacter jejuni were studied in rabbits receiving gastric inoculation with live organisms. A lavage procedure was used to facilitate repeated monitoring of the intestinal immune response to C. jejuni. Immunity to C. jejuni was determined by secondary challenge by using the removable intestinal tie adult rabbit diarrhea (RITARD) model and monitoring for resistance to colonization and bacteremia. Oral-gastric inoculation of normal rabbits produced a transient intestinal colonization without diarrhea. C. jejuni serotypes differed in their ability to colonize the intestines of rabbits and to stimulate primary intestinal and serum antibody responses. Animals previously colonized were resistant to recolonization and the development of bacteremia after homologous challenge by the RITARD procedure but were not resistant to heterologous challenges. Anticampylobacter intestinal and serum IgA titers before this secondary infection were the most reliable predictors of resistance to colonization and bacteremia.

Original languageEnglish (US)
Pages (from-to)99-105
Number of pages7
JournalInfection and Immunity
Volume56
Issue number1
StatePublished - 1988
Externally publishedYes

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Mucosal Immunity
Campylobacter jejuni
Stomach
Rabbits
Bacteremia
Diarrhea
Immunologic Monitoring
Therapeutic Irrigation
Serum
Coinfection
Immunoglobulin A
Intestines
Antibody Formation
Immunity

ASJC Scopus subject areas

  • Immunology

Cite this

Burr, D. H., Caldwell, M. B., Bourgeois, L., Morgan, H. R., Wistar, R., & Walker, R. I. (1988). Mucosal and systemic immunity to Campylobacter jejuni in rabbits after gastric inoculation. Infection and Immunity, 56(1), 99-105.

Mucosal and systemic immunity to Campylobacter jejuni in rabbits after gastric inoculation. / Burr, D. H.; Caldwell, M. B.; Bourgeois, Louis; Morgan, H. R.; Wistar, R.; Walker, R. I.

In: Infection and Immunity, Vol. 56, No. 1, 1988, p. 99-105.

Research output: Contribution to journalArticle

Burr, DH, Caldwell, MB, Bourgeois, L, Morgan, HR, Wistar, R & Walker, RI 1988, 'Mucosal and systemic immunity to Campylobacter jejuni in rabbits after gastric inoculation', Infection and Immunity, vol. 56, no. 1, pp. 99-105.
Burr, D. H. ; Caldwell, M. B. ; Bourgeois, Louis ; Morgan, H. R. ; Wistar, R. ; Walker, R. I. / Mucosal and systemic immunity to Campylobacter jejuni in rabbits after gastric inoculation. In: Infection and Immunity. 1988 ; Vol. 56, No. 1. pp. 99-105.
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