Mucoepidermoid carcinoma of the parotid gland: The Mayo Clinic experience

Derek O Boahene, Kerry D. Olsen, Jean E. Lewis, A. Daniel Pinheiro, Vernon Shane Pankratz, Stephanie M. Bagniewski

Research output: Contribution to journalArticle

Abstract

Objective: To determine clinical and histopathologic features of mucoepidermoid carcinoma of the parotid gland, specifically, the relation of tumor stage and grade and treatment type with clinical outcome. Design: Retrospective clinical and histopathologic review. Setting: Tertiary care medical center. Patients: From 1940 to 1994, 128 patients were treated at our institution for parotid mucoepidermoid carcinoma. Eighty-nine of these patients had their first treatment at our institution; these cases were chosen for retrospective clinical and histopathologic review. Intervention: A head and neck pathologist independently reviewed the pathology specimens. Main Outcome Measures: Age, symptoms, stage, treatment type, tumor grade, pathological features, disease progression, and survival. Results: Results of clinical staging were: T1 in 56 patients, T2 in 13, T3 in 1, T4 in 15, NO in 85, N1 in 2, and N2 in 2. No patient had N3 or M1 disease. All patients underwent parotidectomy with or without neck dissection. Seven patients received postoperative radiotherapy. Tumor grade was low in 43 patients (48%), intermediate in 40 (45%), and high in 6 (7%). Only 5 patients had disease progression (local recurrence in 4, regional recurrence in 4, and distant recurrence in 2). At latest follow-up (mean follow-up, 14.7 years), 64 patients were alive without disease, 1 was alive with disease, 2 had died of mucoepidermoid carcinoma, and 22 had died of other causes. The Kaplan-Meier estimated cancer-specific survival rates at 5, 1.5, and 25 years were 98.8%, 97.4%, and 97.4%, respectively. Conclusions: In our study, tumor grade and stage appeared to be less important than previously described. With adequate parotidectomy and appropriate neck dissection, patients with mucoepidermoid carcinoma of the parotid gland appear to do well, with few recurrences.

Original languageEnglish (US)
Pages (from-to)849-856
Number of pages8
JournalArchives of Otolaryngology--Head and Neck Surgery
Volume130
Issue number7
DOIs
StatePublished - Jul 2004
Externally publishedYes

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Mucoepidermoid Carcinoma
Parotid Gland
Recurrence
Neck Dissection
Neoplasms
Disease Progression
Tertiary Care Centers
Neck
Radiotherapy
Therapeutics
Survival Rate

ASJC Scopus subject areas

  • Otorhinolaryngology

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Mucoepidermoid carcinoma of the parotid gland : The Mayo Clinic experience. / Boahene, Derek O; Olsen, Kerry D.; Lewis, Jean E.; Pinheiro, A. Daniel; Pankratz, Vernon Shane; Bagniewski, Stephanie M.

In: Archives of Otolaryngology--Head and Neck Surgery, Vol. 130, No. 7, 07.2004, p. 849-856.

Research output: Contribution to journalArticle

Boahene, Derek O ; Olsen, Kerry D. ; Lewis, Jean E. ; Pinheiro, A. Daniel ; Pankratz, Vernon Shane ; Bagniewski, Stephanie M. / Mucoepidermoid carcinoma of the parotid gland : The Mayo Clinic experience. In: Archives of Otolaryngology--Head and Neck Surgery. 2004 ; Vol. 130, No. 7. pp. 849-856.
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abstract = "Objective: To determine clinical and histopathologic features of mucoepidermoid carcinoma of the parotid gland, specifically, the relation of tumor stage and grade and treatment type with clinical outcome. Design: Retrospective clinical and histopathologic review. Setting: Tertiary care medical center. Patients: From 1940 to 1994, 128 patients were treated at our institution for parotid mucoepidermoid carcinoma. Eighty-nine of these patients had their first treatment at our institution; these cases were chosen for retrospective clinical and histopathologic review. Intervention: A head and neck pathologist independently reviewed the pathology specimens. Main Outcome Measures: Age, symptoms, stage, treatment type, tumor grade, pathological features, disease progression, and survival. Results: Results of clinical staging were: T1 in 56 patients, T2 in 13, T3 in 1, T4 in 15, NO in 85, N1 in 2, and N2 in 2. No patient had N3 or M1 disease. All patients underwent parotidectomy with or without neck dissection. Seven patients received postoperative radiotherapy. Tumor grade was low in 43 patients (48{\%}), intermediate in 40 (45{\%}), and high in 6 (7{\%}). Only 5 patients had disease progression (local recurrence in 4, regional recurrence in 4, and distant recurrence in 2). At latest follow-up (mean follow-up, 14.7 years), 64 patients were alive without disease, 1 was alive with disease, 2 had died of mucoepidermoid carcinoma, and 22 had died of other causes. The Kaplan-Meier estimated cancer-specific survival rates at 5, 1.5, and 25 years were 98.8{\%}, 97.4{\%}, and 97.4{\%}, respectively. Conclusions: In our study, tumor grade and stage appeared to be less important than previously described. With adequate parotidectomy and appropriate neck dissection, patients with mucoepidermoid carcinoma of the parotid gland appear to do well, with few recurrences.",
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