Mucinous borderline ovarian tumors: Points of general agreement and persistent controversies regarding nomenclature, diagnostic criteria, and behavior

Brigitte Maria Ronnett, André Kajdacsy-Balla, C. Blake Gilks, Maria J. Merino, Elvio Silva, Bruce A. Werness, Robert H. Young

Research output: Contribution to journalArticle

Abstract

This report focuses on the borderline category of ovarian mucinous tumors and summarizes the points of general agreement and persistent controversies identified by experts in the field who participated in the Borderline Ovarian Tumor Workshop held in Bethesda, MD, in August 2003. Points of agreement and persistent controversies regarding nomenclature, diagnostic criteria, and behavior are addressed for the following ovarian mucinous tumor categories: mucinous borderline ovarian tumor (M-BOT; synonymously referred to as atypical proliferative mucinous tumor of ovary or mucinous ovarian tumor of low malignant potential), M-BOT with intraepithelial carcinoma, and M-BOT with microinvasion. The morphologic spectrum of M-BOTs with regard to distinction from mucinous cystadenoma and the confluent glandular/expansile type of invasive mucinous carcinoma is also addressed. Non-ovarian mucinous tumors, including the secondary ovarian mucinous tumors associated with pseudomyxoma peritonei and metastatic mucinous carcinomas with a deceptive pattern of invasion, are recognized as tumors that can simulate primary M-BOTs. Improved classification of these mucinous tumors has clarifed the behavior of true M-BOTs by excluding these simulators from the M-BOT category.

Original languageEnglish (US)
Pages (from-to)949-960
Number of pages12
JournalHuman Pathology
Volume35
Issue number8
DOIs
StatePublished - Aug 2004

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Terminology
Neoplasms
Mucinous Adenocarcinoma
Pseudomyxoma Peritonei
Mucinous Cystadenoma
Carcinoma in Situ
Ovary
Education

Keywords

  • atypical proliferative mucinous tumor
  • CK
  • cytokeratin
  • FIGO
  • International Federation of Gynecology and Obstetrics
  • M-BOT
  • mucinous borderline ovarian tumor
  • mucinous tumor of low malignant potential
  • ovary
  • PMP

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Mucinous borderline ovarian tumors : Points of general agreement and persistent controversies regarding nomenclature, diagnostic criteria, and behavior. / Ronnett, Brigitte Maria; Kajdacsy-Balla, André; Gilks, C. Blake; Merino, Maria J.; Silva, Elvio; Werness, Bruce A.; Young, Robert H.

In: Human Pathology, Vol. 35, No. 8, 08.2004, p. 949-960.

Research output: Contribution to journalArticle

Ronnett, Brigitte Maria ; Kajdacsy-Balla, André ; Gilks, C. Blake ; Merino, Maria J. ; Silva, Elvio ; Werness, Bruce A. ; Young, Robert H. / Mucinous borderline ovarian tumors : Points of general agreement and persistent controversies regarding nomenclature, diagnostic criteria, and behavior. In: Human Pathology. 2004 ; Vol. 35, No. 8. pp. 949-960.
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