Much Ado about Zero

Jef D. Boeke, David Fenyo

Research output: Contribution to journalShort survey


LINE retrotransposons actively shape mammalian genomes. Denli et al. reveal a new open reading frame, ORF0, on the antisense strand of human LINE-1 encoding a small regulatory protein. This finding may represent the birth of an emerging retrotransposon gene that can adopt various fates, as it can be fused to adjacent host sequences.

Original languageEnglish (US)
Pages (from-to)534-535
Number of pages2
Issue number3
StatePublished - Oct 22 2015


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Boeke, J. D., & Fenyo, D. (2015). Much Ado about Zero. Cell, 163(3), 534-535.