MTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis

R. W. Hallowell, S. L. Collins, J. M. Craig, Y. Zhang, M. Oh, P. B. Illei, Y. Chan-Li, C. L. Vigeland, W. Mitzner, A. L. Scott, J. D. Powell, M. R. Horton

Research output: Research - peer-reviewArticle

Abstract

Alternatively activated macrophages (M2) have an important function in innate immune responses to parasitic helminths, and emerging evidence also indicates these cells are regulators of systemic metabolism. Here we show a critical role for mTORC2 signalling in the generation of M2 macrophages. Abrogation of mTORC2 signalling in macrophages by selective conditional deletion of the adaptor molecule Rictor inhibits the generation of M2 macrophages while leaving the generation of classically activated macrophages (M1) intact. Selective deletion of Rictor in macrophages prevents M2 differentiation and clearance of a parasitic helminth infection in mice, and also abrogates the ability of mice to regulate brown fat and maintain core body temperature. Our findings define a role for mTORC2 in macrophages in integrating signals from the immune microenvironment to promote innate type 2 immunity, and also to integrate systemic metabolic and thermogenic responses.

LanguageEnglish (US)
Article number14208
JournalNature Communications
Volume8
DOIs
StatePublished - Jan 27 2017

Fingerprint

Thermogenesis
Helminths
Macrophages
Infection
macrophages
infectious diseases
TOR complex 2
Innate Immunity
deletion
mice
Parasitic Diseases
Brown Adipose Tissue
Body Temperature
body temperature
regulators
fats
immunity
clearances
metabolism
emerging

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

MTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis. / Hallowell, R. W.; Collins, S. L.; Craig, J. M.; Zhang, Y.; Oh, M.; Illei, P. B.; Chan-Li, Y.; Vigeland, C. L.; Mitzner, W.; Scott, A. L.; Powell, J. D.; Horton, M. R.

In: Nature Communications, Vol. 8, 14208, 27.01.2017.

Research output: Research - peer-reviewArticle

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AU - Chan-Li,Y.

AU - Vigeland,C. L.

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