MRS characterization of central neurocytomas using glycine

Tariq Shah, Rama Jayasundar, Virendera Paul Singh, Chitra Sarkar

Research output: Contribution to journalArticle

Abstract

This study reports in vivo MRS findings in 11 patients with histologically diagnosed central neurocytomas, which are rare intraventricular tumors of neuronal origin. Single-voxel 1H MRS was carried out prior to surgery using a point-resolved spectroscopy sequence with TR=6s, TE=135ms and 128 scans. In vitro high-resolution 1H spectroscopy was also carried out on two surgically excised samples. The striking features of the spectra from the central neurocytomas were the presence of high glycine, decreased N-acetylaspartate, increased choline and alanine. Retrospective, blind analysis of the spectra by two independent observers correctly identified all but one central neurocytoma based on the presence of glycine. The presence of glycine and prominent choline in the 1H MR spectrum is a characteristic feature of the central neurocytomas, and could be used to characterize and differentiate them from other brain tumors.

Original languageEnglish (US)
Pages (from-to)1408-1413
Number of pages6
JournalNMR in biomedicine
Volume24
Issue number10
DOIs
StatePublished - Dec 1 2011

Keywords

  • Alanine
  • Central neurocytomas
  • Choline
  • Glycine
  • H MRS
  • High-resolution NMR spectroscopy
  • Intraventricular tumor
  • N-acetylaspartate

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

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  • Cite this

    Shah, T., Jayasundar, R., Singh, V. P., & Sarkar, C. (2011). MRS characterization of central neurocytomas using glycine. NMR in biomedicine, 24(10), 1408-1413. https://doi.org/10.1002/nbm.1705