MRS and MRSI guidance in molecular medicine: Targeting and monitoring of choline and glucose metabolism in cancer

Kristine Glunde, Lu Jiang, Siver A. Moestue, Ingrid S. Gribbestad

Research output: Contribution to journalReview articlepeer-review

Abstract

MRS and MRSI are valuable tools for the detection of metabolic changes in tumors. The currently emerging era of molecular medicine, which is shaped by molecularly targeted anticancer therapies combined with molecular imaging of the effects of such therapies, requires powerful imaging technologies that are able to detect molecular information. MRS and MRSI are such technologies that are able to detect metabolites arising from glucose and choline metabolism in noninvasive in vivo settings and at higher resolution in tissue samples. The roles played by MRS and MRSI in the diagnosis of different types of cancer, as well as in the early monitoring of the tumor response to traditional chemotherapies, are reviewed. The emerging roles of MRS and MRSI in the development and detection of novel targeted anticancer therapies that target oncogenic signaling pathways or markers in choline or glucose metabolism are discussed.

Original languageEnglish (US)
Pages (from-to)673-690
Number of pages18
JournalNMR in biomedicine
Volume24
Issue number6
DOIs
StatePublished - Jul 2011

Keywords

  • Choline
  • Glucose
  • MRS
  • Metabolism

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

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