MRNA profiles of cytokine receptor in unstimulated peripheral blood mononuclear cells from patients with chronic idiopathic urticaria

Jianming Gao, Aizhen Yang, Min Chen, Ansheng Li, Xu Yao, Yumei Li, Shihai Xie, Xueyuan Yang, Liansheng Zhong, Zhiqiang Chen

Research output: Contribution to journalArticle

Abstract

This present study was aimed to investigate the roles of the receptors of Th1/Th2 cytokines and chemokines in the pathogenesis of chronic idiopathic urticaria (CIU). Thirty patients with CIU, 30 patients with dermographism and 30 healthy controls were randomly enrolled. Reverse transcription-PCR (RT-PCR) was used to analyze the mRNA of cytokine receptors in peripheral blood mononuclear cells (PBMCs). The mRNA levels of tumor necrosis factor receptor (TNFR), interferon-γ receptor (IFN-γR), and interleukin-10 receptor (IL-10R) were statistically increased in the CIU group (P <0.05), while IL-2R, IL-4R, IL-6R, and IL-13R showed no significant differences between the CIU and other groups. The mRNA levels of CCR3 and CCR6 were statistically increased in the CIU group (P <0.05). The toll-like receptor 2 (TLR2) mRNA level was significantly lower in the CIU group than the healthy control group (P <0.05). These findings indicate that the regulation of mRNA of TNFR, IFN-γR, IL-10R, CCR3, CCR6 and TLR2 may be involved in the pathogenesis of CIU.

Original languageEnglish (US)
Pages (from-to)141-147
Number of pages7
JournalJournal of Biomedical Research
Volume25
Issue number2
DOIs
StatePublished - Mar 2011
Externally publishedYes

Keywords

  • Chemokine
  • Cytokine
  • Receptor
  • Urticaria

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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