TY - JOUR
T1 - MRNA profiles of cytokine receptor in unstimulated peripheral blood mononuclear cells from patients with chronic idiopathic urticaria
AU - Gao, Jianming
AU - Yang, Aizhen
AU - Chen, Min
AU - Li, Ansheng
AU - Yao, Xu
AU - Li, Yumei
AU - Xie, Shihai
AU - Yang, Xueyuan
AU - Zhong, Liansheng
AU - Chen, Zhiqiang
PY - 2011/3
Y1 - 2011/3
N2 - This present study was aimed to investigate the roles of the receptors of Th1/Th2 cytokines and chemokines in the pathogenesis of chronic idiopathic urticaria (CIU). Thirty patients with CIU, 30 patients with dermographism and 30 healthy controls were randomly enrolled. Reverse transcription-PCR (RT-PCR) was used to analyze the mRNA of cytokine receptors in peripheral blood mononuclear cells (PBMCs). The mRNA levels of tumor necrosis factor receptor (TNFR), interferon-γ receptor (IFN-γR), and interleukin-10 receptor (IL-10R) were statistically increased in the CIU group (P <0.05), while IL-2R, IL-4R, IL-6R, and IL-13R showed no significant differences between the CIU and other groups. The mRNA levels of CCR3 and CCR6 were statistically increased in the CIU group (P <0.05). The toll-like receptor 2 (TLR2) mRNA level was significantly lower in the CIU group than the healthy control group (P <0.05). These findings indicate that the regulation of mRNA of TNFR, IFN-γR, IL-10R, CCR3, CCR6 and TLR2 may be involved in the pathogenesis of CIU.
AB - This present study was aimed to investigate the roles of the receptors of Th1/Th2 cytokines and chemokines in the pathogenesis of chronic idiopathic urticaria (CIU). Thirty patients with CIU, 30 patients with dermographism and 30 healthy controls were randomly enrolled. Reverse transcription-PCR (RT-PCR) was used to analyze the mRNA of cytokine receptors in peripheral blood mononuclear cells (PBMCs). The mRNA levels of tumor necrosis factor receptor (TNFR), interferon-γ receptor (IFN-γR), and interleukin-10 receptor (IL-10R) were statistically increased in the CIU group (P <0.05), while IL-2R, IL-4R, IL-6R, and IL-13R showed no significant differences between the CIU and other groups. The mRNA levels of CCR3 and CCR6 were statistically increased in the CIU group (P <0.05). The toll-like receptor 2 (TLR2) mRNA level was significantly lower in the CIU group than the healthy control group (P <0.05). These findings indicate that the regulation of mRNA of TNFR, IFN-γR, IL-10R, CCR3, CCR6 and TLR2 may be involved in the pathogenesis of CIU.
KW - Chemokine
KW - Cytokine
KW - Receptor
KW - Urticaria
UR - http://www.scopus.com/inward/record.url?scp=79955154752&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955154752&partnerID=8YFLogxK
U2 - 10.1016/S1674-8301(11)60018-3
DO - 10.1016/S1674-8301(11)60018-3
M3 - Article
C2 - 23554682
AN - SCOPUS:79955154752
SN - 1674-8301
VL - 25
SP - 141
EP - 147
JO - Journal of Biomedical Research
JF - Journal of Biomedical Research
IS - 2
ER -