mRNA expression of chemokine receptors on peripheral blood mononuclear cells and correlation with clinical features in systemic lupus erythematosus patients

Yu Mei Li, Zhi Qiang Chen, Xu Yao, Ai Zhen Yang, An Sheng Li, Dong Ming Liu, Juan Qin Gong

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To investigate the expressions of chemokine receptors and interleukin (IL) receptors on the peripheral blood mononuclear cells (PBMCs) from systemic lupus erythematosus (SLE) patients and their correlations with clinical features as well as SLE disease activity index (SLEDAI). Methods: The mRNA expressions of chemokine receptors and IL receptors on PBMCs of 93 SLE patients and 30 healthy controls were detected by reverse transcription- polymerase chain reaction, including CCR2, CCR3, CCR4, CCR5, CCR6, CCR8, CXCR3, CXCR5, CX3CR1, XCR1, IL-4R, and IL-10R. The clinical features of SLE patients were recorded. The correlations of chemokine receptors and IL receptors mRNA expressions with clinical features as well as SLEDAI were assayed using linear regression analysis. Results: The level of CCRS mRNA in SLE patients (including active and inactive SLE) was significantly higher than that in healthy controls (P0.05). CX3CR1 mRNA expression significantly increased from healthy control to inactive SLE to active SLE in sequence. The others (except for CCR8, CXCR3, and IL-10R) in active SLE patients were significantly higher than those in both inactive SLE patients and healthy controls (all P

Original languageEnglish (US)
Pages (from-to)162-168
Number of pages7
JournalChinese Medical Sciences Journal
Volume25
Issue number3
DOIs
StatePublished - Sep 2010
Externally publishedYes

Keywords

  • Chemokine receptors
  • Peripheral blood mononuclear cell
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Medicine(all)

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