Mr/k hemagglutination of providencia stuartii correlates with adherence to catheters and with persistence in catheter-associated bacteriuria

Harry L. Harry, Gwynn R. Chippendale, James H. Tenney, Andrew R. Mayrer, Lesley J. Crisp, John L. Penner, John W. Warren, Harry L. Harry

Research output: Contribution to journalArticle

Abstract

Providencia stuartii was the most prevalent bacterial species isolated, for one year, from weekly urine specimens from 51 long-term catheterized patients. Significantly more strains causing bacteriuric episodes of long duration expressed MR/K (mannose-resistant/A’feft-.sve/fa-like) hemagglutination (74%) than did those causing episodes of short duration (26%; P =.004). Isolates expressing MR/K hemagglutinin bound in higher numbers to catheter material (P =.023) than did those not expressing this hemagglutinin. Significantly more strains causing bacteriuric episodes of short duration expressed the mannose- sensitive (MS) hemagglutinin (43%) than did those causing episodes of long duration (7%; P =.014). Isolates expressing MS hemagglutinin bound significantly more125I-labeled Tamm-Horsfall protein (THP) than did isolates not expressing this hemagglutinin (P =.0001). Our results indicate that MR/K hemagglutinin plays an important role in the ability of P. stuartii to persist and suggest that MR/K adheres to the catheter. Conversely, MS hemagglutinin binds to THP and may prevent persistence of P. stuartii in the catheterized urinary tract.

Original languageEnglish (US)
Pages (from-to)264-271
Number of pages8
JournalJournal of Infectious Diseases
Volume157
Issue number2
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Providencia
Bacteriuria
Hemagglutination
Hemagglutinins
Catheters
Mannose
Uromodulin
Urinary Tract
Urine

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Mr/k hemagglutination of providencia stuartii correlates with adherence to catheters and with persistence in catheter-associated bacteriuria. / Harry, Harry L.; Chippendale, Gwynn R.; Tenney, James H.; Mayrer, Andrew R.; Crisp, Lesley J.; Penner, John L.; Warren, John W.; Harry, Harry L.

In: Journal of Infectious Diseases, Vol. 157, No. 2, 1988, p. 264-271.

Research output: Contribution to journalArticle

Harry, HL, Chippendale, GR, Tenney, JH, Mayrer, AR, Crisp, LJ, Penner, JL, Warren, JW & Harry, HL 1988, 'Mr/k hemagglutination of providencia stuartii correlates with adherence to catheters and with persistence in catheter-associated bacteriuria', Journal of Infectious Diseases, vol. 157, no. 2, pp. 264-271. https://doi.org/10.1093/infdis/157.2.264
Harry, Harry L. ; Chippendale, Gwynn R. ; Tenney, James H. ; Mayrer, Andrew R. ; Crisp, Lesley J. ; Penner, John L. ; Warren, John W. ; Harry, Harry L. / Mr/k hemagglutination of providencia stuartii correlates with adherence to catheters and with persistence in catheter-associated bacteriuria. In: Journal of Infectious Diseases. 1988 ; Vol. 157, No. 2. pp. 264-271.
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