Mr/k hemagglutination of providencia stuartii correlates with adherence to catheters and with persistence in catheter-associated bacteriuria

Harry L. Harry, Gwynn R. Chippendale, James H. Tenney, Andrew R. Mayrer, Lesley J. Crisp, John L. Penner, John W. Warren, Harry L. Harry

Research output: Contribution to journalArticle

Abstract

Providencia stuartii was the most prevalent bacterial species isolated, for one year, from weekly urine specimens from 51 long-term catheterized patients. Significantly more strains causing bacteriuric episodes of long duration expressed MR/K (mannose-resistant/A’feft-.sve/fa-like) hemagglutination (74%) than did those causing episodes of short duration (26%; P =.004). Isolates expressing MR/K hemagglutinin bound in higher numbers to catheter material (P =.023) than did those not expressing this hemagglutinin. Significantly more strains causing bacteriuric episodes of short duration expressed the mannose- sensitive (MS) hemagglutinin (43%) than did those causing episodes of long duration (7%; P =.014). Isolates expressing MS hemagglutinin bound significantly more125I-labeled Tamm-Horsfall protein (THP) than did isolates not expressing this hemagglutinin (P =.0001). Our results indicate that MR/K hemagglutinin plays an important role in the ability of P. stuartii to persist and suggest that MR/K adheres to the catheter. Conversely, MS hemagglutinin binds to THP and may prevent persistence of P. stuartii in the catheterized urinary tract.

Original languageEnglish (US)
Pages (from-to)264-271
Number of pages8
JournalJournal of Infectious Diseases
Volume157
Issue number2
DOIs
StatePublished - Feb 1988

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Harry, H. L., Chippendale, G. R., Tenney, J. H., Mayrer, A. R., Crisp, L. J., Penner, J. L., Warren, J. W., & Harry, H. L. (1988). Mr/k hemagglutination of providencia stuartii correlates with adherence to catheters and with persistence in catheter-associated bacteriuria. Journal of Infectious Diseases, 157(2), 264-271. https://doi.org/10.1093/infdis/157.2.264