MRI techniques to measure arterial and venous cerebral blood volume

Jun Hua, Peiying Liu, Tae Kim, Manus Donahue, Swati Rane, J. Jean Chen, Qin Qin, Seong Gi Kim

Research output: Contribution to journalArticle

Abstract

The measurement of cerebral blood volume (CBV) has been the topic of numerous neuroimaging studies. To date, however, most in vivo imaging approaches can only measure CBV summed over all types of blood vessels, including arterial, capillary and venous vessels in the microvasculature (i.e. total CBV or CBVtot). As different types of blood vessels have intrinsically different anatomy, function and physiology, the ability to quantify CBV in different segments of the microvascular tree may furnish information that is not obtainable from CBVtot, and may provide a more sensitive and specific measure for the underlying physiology. This review attempts to summarize major efforts in the development of MRI techniques to measure arterial (CBVa) and venous CBV (CBVv) separately. Advantages and disadvantages of each type of method are discussed. Applications of some of the methods in the investigation of flow-volume coupling in healthy brains, and in the detection of pathophysiological abnormalities in brain diseases such as arterial steno-occlusive disease, brain tumors, schizophrenia, Huntington's disease, Alzheimer's disease, and hypertension are demonstrated. We believe that the continual development of MRI approaches for the measurement of compartment-specific CBV will likely provide essential imaging tools for the advancement and refinement of our knowledge on the exquisite details of the microvasculature in healthy and diseased brains.

Original languageEnglish (US)
JournalNeuroImage
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Brain Diseases
Microvessels
Blood Vessels
Arterial Occlusive Diseases
Aptitude
Huntington Disease
Neuroimaging
Brain Neoplasms
Cerebral Blood Volume
Anatomy
Schizophrenia
Alzheimer Disease
Hypertension
Brain

Keywords

  • Arteriole
  • Capillary
  • CBV
  • MRI
  • Pial artery
  • Vein
  • Venule

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Hua, J., Liu, P., Kim, T., Donahue, M., Rane, S., Chen, J. J., ... Kim, S. G. (Accepted/In press). MRI techniques to measure arterial and venous cerebral blood volume. NeuroImage. https://doi.org/10.1016/j.neuroimage.2018.02.027

MRI techniques to measure arterial and venous cerebral blood volume. / Hua, Jun; Liu, Peiying; Kim, Tae; Donahue, Manus; Rane, Swati; Chen, J. Jean; Qin, Qin; Kim, Seong Gi.

In: NeuroImage, 01.01.2018.

Research output: Contribution to journalArticle

Hua, Jun ; Liu, Peiying ; Kim, Tae ; Donahue, Manus ; Rane, Swati ; Chen, J. Jean ; Qin, Qin ; Kim, Seong Gi. / MRI techniques to measure arterial and venous cerebral blood volume. In: NeuroImage. 2018.
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