MRI parcellation of the frontal lobe in boys with attention deficit hyperactivity disorder or Tourette syndrome

Wendy R. Kates, Melissa Frederikse, Stewart H Mostofsky, Bradley S. Folley, Karen Cooper, Patricia Mazur-Hopkins, Ora Kofman, Harvey Singer, Martha Bridge Denckla, Godfrey D. Pearlson, Walter E. Kaufmann

Research output: Contribution to journalArticle

Abstract

Dysfunction of frontal-striatal-thalamic-frontal circuitry has been hypothesized to underlie both attention deficit hyperactivity disorder (ADHD) and Tourette syndrome (TS). Several research groups have therefore used anatomic magnetic resonance imaging (aMRI) to obtain volumetric measurements of subregions of the frontal lobe in these disorders. Most previous studies have relied on subparcellation methods that utilize callosal landmarks to derive subregions of the frontal lobe. In contrast, we present here an investigation of frontal lobe morphometry in ADHD and TS based on a reliable frontal subparcellation protocol that combines contiguous sulcal/gyral boundaries to derive frontal lobe modules based on prior functional studies. This highly reliable procedure subdivides the frontal lobe into five major modules: prefrontal, premotor, motor (precentral gyrus), anterior cingulate, and deep white matter. The first four modules are also segmented into gray and gyral white matter compartments. The protocol was applied to T1-weighted, SPGR coronal MRI images of 13 school-aged boys with ADHD, 13 boys with TS, and 13 age- and gender-matched controls. In ADHD, we found volumetric reductions in both the gray and white matter of the prefrontal cortex. These findings, in conjunction with previous reports on basal ganglia abnormalities, suggest that prefrontal-striatal pathways may be anomalous in ADHD. In TS, we found volumetric decreases in the left deep frontal white matter. Decreases in deep white matter suggest the presence of abnormalities in long associational and projection fiber bundles in TS. The findings of this study both confirm and extend our knowledge of the neurobiology of ADHD and TS, indicating that the reliable parcellation method presented has the potential of increasing our understanding of the role of the frontal lobe in developmental and psychiatric disorders.

Original languageEnglish (US)
Pages (from-to)63-81
Number of pages19
JournalPsychiatry Research - Neuroimaging
Volume116
Issue number1-2
DOIs
StatePublished - Nov 30 2002

Fingerprint

Tourette Syndrome
Frontal Lobe
Attention Deficit Disorder with Hyperactivity
Corpus Striatum
Neurobiology
Corpus Callosum
Gyrus Cinguli
Basal Ganglia
Prefrontal Cortex
Psychiatry
Magnetic Resonance Imaging
White Matter
Research

Keywords

  • Anatomic MRI
  • Attention deficit hyperactivity disorder
  • Children
  • Prefrontal cortex
  • Prefrontal-striatal circuitry

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Cite this

MRI parcellation of the frontal lobe in boys with attention deficit hyperactivity disorder or Tourette syndrome. / Kates, Wendy R.; Frederikse, Melissa; Mostofsky, Stewart H; Folley, Bradley S.; Cooper, Karen; Mazur-Hopkins, Patricia; Kofman, Ora; Singer, Harvey; Denckla, Martha Bridge; Pearlson, Godfrey D.; Kaufmann, Walter E.

In: Psychiatry Research - Neuroimaging, Vol. 116, No. 1-2, 30.11.2002, p. 63-81.

Research output: Contribution to journalArticle

Kates, Wendy R. ; Frederikse, Melissa ; Mostofsky, Stewart H ; Folley, Bradley S. ; Cooper, Karen ; Mazur-Hopkins, Patricia ; Kofman, Ora ; Singer, Harvey ; Denckla, Martha Bridge ; Pearlson, Godfrey D. ; Kaufmann, Walter E. / MRI parcellation of the frontal lobe in boys with attention deficit hyperactivity disorder or Tourette syndrome. In: Psychiatry Research - Neuroimaging. 2002 ; Vol. 116, No. 1-2. pp. 63-81.
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