MRI mapping of cerebrovascular reactivity via gas inhalation challenges

Hanzhang Lu, Peiying Liu, Uma Yezhuvath, Yamei Cheng, Olga Marshall, Yulin Ge

Research output: Contribution to journalArticle

Abstract

The brain is a spatially heterogeneous and temporally dynamic organ, with different regions requiring different amount of blood supply at different time. Therefore, the ability of the blood vessels to dilate or constrict, known as Cerebral-Vascular-Reactivity (CVR), represents an important domain of vascular function. An imaging marker representing this dynamic property will provide new information of cerebral vessels under normal and diseased conditions such as stroke, dementia, atherosclerosis, small vessel diseases, brain tumor, traumatic brain injury, and multiple sclerosis. In order to perform this type of measurement in humans, it is necessary to deliver a vasoactive stimulus such as CO2 and/or O2 gas mixture while quantitative brain magnetic resonance images (MRI) are being collected. In this work, we presented a MR compatible gas-delivery system and the associated protocol that allow the delivery of special gas mixtures (e.g., O2, CO2, N2, and their combinations) while the subject is lying inside the MRI scanner. This system is relatively simple, economical, and easy to use, and the experimental protocol allows accurate mapping of CVR in both healthy volunteers and patients with neurological disorders. This approach has the potential to be used in broad clinical applications and in better understanding of brain vascular pathophysiology. In the video, we demonstrate how to set up the system inside an MRI suite and how to perform a complete experiment on a human participant.

Original languageEnglish (US)
JournalJournal of visualized experiments : JoVE
Issue number94
DOIs
StatePublished - Dec 17 2014
Externally publishedYes

Fingerprint

Magnetic resonance
Inhalation
Blood Vessels
Brain
Magnetic Resonance Spectroscopy
Gases
Gas mixtures
Aptitude
Blood vessels
Nervous System Diseases
Brain Neoplasms
Multiple Sclerosis
Dementia
Tumors
Atherosclerosis
Healthy Volunteers
Blood
Stroke
Imaging techniques
Experiments

ASJC Scopus subject areas

  • Neuroscience(all)
  • Chemical Engineering(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

MRI mapping of cerebrovascular reactivity via gas inhalation challenges. / Lu, Hanzhang; Liu, Peiying; Yezhuvath, Uma; Cheng, Yamei; Marshall, Olga; Ge, Yulin.

In: Journal of visualized experiments : JoVE, No. 94, 17.12.2014.

Research output: Contribution to journalArticle

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