TY - JOUR
T1 - MRI High-Intensity Signals in Late-Life Depression and Alzheimer's Disease
T2 - A Comparison of Subjects Without Major Vascular Risk Factors
AU - Miller, David S.
AU - Kumar, Anand
AU - Yousem, David M.
AU - Gottlieb, Gary L.
N1 - Funding Information:
This work was supported in part by an NIMH Clinical Mental Health Academic Award (AK) and by the NIA Alzheimer's Disease Center Core.
PY - 1994
Y1 - 1994
N2 - The authors examined periventricular white matter, deep white matter, and subcortical magnetic resonance imaging (MRI) high-intensity signals in subjects with late-life depression, probable Alzheimer's disease (DAT), and healthy, age-matched controls. All subjects were healthy and free of major vascular risk factors, including hypertension. MRIs were performed using a 1.5-tesla GE Signa scanner. T2 and proton-density-weighted images were analyzed by a neuroradiologist blind to the clinical status of all subjects. There were no statistically significant differences on any of the MRI indices between the groups studied. These data demonstrate that late-life depression, like DAT, in the absence of major vascular risk factors, is not associated with a significant increase in MRI high-intensity signals when compared to healthy, control subjects.
AB - The authors examined periventricular white matter, deep white matter, and subcortical magnetic resonance imaging (MRI) high-intensity signals in subjects with late-life depression, probable Alzheimer's disease (DAT), and healthy, age-matched controls. All subjects were healthy and free of major vascular risk factors, including hypertension. MRIs were performed using a 1.5-tesla GE Signa scanner. T2 and proton-density-weighted images were analyzed by a neuroradiologist blind to the clinical status of all subjects. There were no statistically significant differences on any of the MRI indices between the groups studied. These data demonstrate that late-life depression, like DAT, in the absence of major vascular risk factors, is not associated with a significant increase in MRI high-intensity signals when compared to healthy, control subjects.
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U2 - 10.1097/00019442-199402040-00008
DO - 10.1097/00019442-199402040-00008
M3 - Article
C2 - 28530983
AN - SCOPUS:0027988560
SN - 1064-7481
VL - 2
SP - 332
EP - 337
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
IS - 4
ER -