MRI-guided SPECT perfusion measures and volumetric MRI in prodromal Alzheimer disease

Georges El Fakhri, Marie Foley Kijewski, Keith A. Johnson, Grigoriy Syrkin, Ronald J. Killiany, J. Alex Becker, Robert E. Zimmerman, Marilyn S. Albert

Research output: Contribution to journalArticle

Abstract

Objective: To identify group differences in the prodromal phase of Alzheimer disease (AD) using quantitative single-photon emission computed tomography (SPECT) perfusion and magnetic resonance imaging (MRI) volume measures within specific volumes of interest. Setting: Gerontology research unit. Participants: There were 17 healthy controls, 56 non-demented patients with memory problems who did not develop AD during 3 to 5 years of follow-up (questionables), and 27 nondemented patients with memory problems who developed AD during follow-up (converters). Methods: A Tc 99m hexamethylpropyleneamine oxime SPECT study and an MRI were performed in each participant at baseline. Mean SPECT activity concentration and MRI volume were estimated within 9 structures: rostral anterior cingulate, caudal anterior cingulate, posterior cingulate, hippocampus, entorhinal cortex, basal forebrain, temporal horn, amygdala, and the banks of the superior temporal sulcus. Data were analyzed using overall and pairwise discriminant analysis, and performance in pairwise group discrimination was measured using correlated receiver operating characteristic curve analysis. Results: The overall (3-group) discriminant function was significant for SPECT (F test, P<.001) and MRI (F test, P<.0001). For the SPECT analysis, the ranking of structures for discriminating among the 3 groups was, in order of decreasing discriminating power, caudal anterior cingulate, temporal horn, superior temporal sulcus, entorhinal cortex, hippocampus, rostral anterior cingulate, amygdala, basal forebrain, and posterior cingulate. For the MRI analysis, this ranking was entorhinal cortex, superior temporal sulcus, temporal horn, hippocampus, amygdala, caudal anterior cingulate, rostral anterior cingulate, basal fore-brain, and posterior cingulate. Combining the 2 modalities yielded significantly better discrimination performance than did either alone. Furthermore, the correlation between SPECT and MRI measures was low. Conclusion: Measures of structure activity concentration and volume carry independent information; both reveal group differences in prodromal AD.

Original languageEnglish (US)
Pages (from-to)1066-1072
Number of pages7
JournalArchives of neurology
Volume60
Issue number8
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

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ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

El Fakhri, G., Kijewski, M. F., Johnson, K. A., Syrkin, G., Killiany, R. J., Becker, J. A., Zimmerman, R. E., & Albert, M. S. (2003). MRI-guided SPECT perfusion measures and volumetric MRI in prodromal Alzheimer disease. Archives of neurology, 60(8), 1066-1072. https://doi.org/10.1001/archneur.60.8.1066