MRI-guided radiofrequency thermal ablation of implanted VX2 liver tumors in a rabbit model: Demonstration of feasibility at 0.2 T

Elmar M. Merkle, Daniel T. Boll, Travis Boaz, Jeffrey L. Duerk, Yio C. Chung, Gretta H. Jacobs, Marie E. Varnes, Jonathan S. Lewin

Research output: Contribution to journalArticlepeer-review

Abstract

Successful radiofrequency (RF) thermal ablation was performed on VX2 tumors implanted in 23 rabbit livers under magnetic resonance (MR) guidance using a C-arm-shaped low-field 0.2 T system. RF application and immediate postprocedure MRI of all animals was performed [T2-weighted, turbo short tau inversion recovery (STIR), T1-weighted before and after gadopentetate dimeglumine administration). Follow-up MRI with a superparamagnetic iron oxide (SPIO) contrast medium was performed in nine rabbits at 2 weeks and in four rabbits at 1 month post RF ablation. All livers were harvested for pathologic examination. T2-weighted and turbo-STIR images demonstrated the highest tumor-to-RF-thermal lesion contrast-to-noise ratios (CNRs; means 4.5 and 3.8, respectively) on postprocedure images; this was redemonstrated at 2- and 4-week follow-up imaging. T2-weighted imaging never overestimated pathologic lesion size by more than 2 mm, and the radiologic-pathologic correlation coefficient was not less than 0.90. In conclusion, MRI-guided RF thermal ablation in implanted liver tumor is feasible using a C-arm-shaped low-field 0.2 T system. The thermal lesion size can be most accurately monitored with T2-weighted and turbo, STIR images.

Original languageEnglish (US)
Pages (from-to)141-149
Number of pages9
JournalMagnetic resonance in medicine
Volume42
Issue number1
DOIs
StatePublished - 1999

Keywords

  • Interstitial thermotherapy
  • Intervention
  • Liver
  • Radiofrequency

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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