TY - JOUR
T1 - MRI-guided percutaneous sclerotherapy of venous malformations
T2 - initial clinical experience using a 3T MRI system
AU - O'Mara, Daniel M.
AU - Berges, Alexandra J.
AU - Fritz, Jan
AU - Weiss, Clifford R.
N1 - Funding Information:
Clifford Weiss, MD, reports grant support from Siemens Healthcare, BTG International Ltd. , Merit Medical and Medtronic and discloses consultant fees from BTG and Medtronic.
Funding Information:
Jan Fritz, MD, reports grant support from Siemens Healthcare, DePuy , Zimmer , Microsoft , and BTG International Ltd. and discloses consultant fees from Siemens Healthcare USA, Alexion Pharmaceuticals , and BTG International Speaker's honorarium from Siemens Healthcare USA.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/9
Y1 - 2020/9
N2 - Purpose: Venous malformations (VMs) are low-flow vascular anomalies that are commonly treated with image-guided percutaneous sclerotherapy. Although many VMs can be safely accessed and treated using ultrasonography and fluoroscopy, some lesions may be better treated with magnetic resonance imaging (MRI)–guided sclerotherapy. The aim of this study is to evaluate the feasibility, efficiency, and outcomes of MRI-guided sclerotherapy of VMs using a 3T MRI system. Methods: Six patients with VMs in the neck (n = 2), chest (n = 1), and extremities (n = 3) underwent sclerotherapy with 3T MRI guidance. Feasibility was assessed by calculating the technical success rate and procedural efficiency. Efficiency was evaluated by using planning, targeting, intervention, and total procedure times. Outcomes were assessed by measuring VM volumes before and after sclerotherapy, patient-reported pain scores, and occurrence of complications. Results: Technical success was achieved in all 6 procedures. There was a non-significant 30% decrease in mean VM volume after the procedure (P = .350). The procedure resulted in a decrease in mean pain score (on an 11-point scale) of 2.6 points (P = .003). After the procedure, 4 patients reported complete pain resolution, 1 reported partial pain resolution, and 1 reported no change in pain. Procedural efficiency was consistent with similar sclerotherapy procedures performed at our institution. There were no major or minor complications. Conclusion: 3T MRI guidance is feasible for percutaneous sclerotherapy of VMs, with promising initial technical success rates, procedural efficiency, and therapeutic outcomes without complications.
AB - Purpose: Venous malformations (VMs) are low-flow vascular anomalies that are commonly treated with image-guided percutaneous sclerotherapy. Although many VMs can be safely accessed and treated using ultrasonography and fluoroscopy, some lesions may be better treated with magnetic resonance imaging (MRI)–guided sclerotherapy. The aim of this study is to evaluate the feasibility, efficiency, and outcomes of MRI-guided sclerotherapy of VMs using a 3T MRI system. Methods: Six patients with VMs in the neck (n = 2), chest (n = 1), and extremities (n = 3) underwent sclerotherapy with 3T MRI guidance. Feasibility was assessed by calculating the technical success rate and procedural efficiency. Efficiency was evaluated by using planning, targeting, intervention, and total procedure times. Outcomes were assessed by measuring VM volumes before and after sclerotherapy, patient-reported pain scores, and occurrence of complications. Results: Technical success was achieved in all 6 procedures. There was a non-significant 30% decrease in mean VM volume after the procedure (P = .350). The procedure resulted in a decrease in mean pain score (on an 11-point scale) of 2.6 points (P = .003). After the procedure, 4 patients reported complete pain resolution, 1 reported partial pain resolution, and 1 reported no change in pain. Procedural efficiency was consistent with similar sclerotherapy procedures performed at our institution. There were no major or minor complications. Conclusion: 3T MRI guidance is feasible for percutaneous sclerotherapy of VMs, with promising initial technical success rates, procedural efficiency, and therapeutic outcomes without complications.
KW - Embolization
KW - Sclerotherapy
KW - Sodium tetradecyl sulfate
KW - Vascular anomaly
KW - Venous malformation
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U2 - 10.1016/j.clinimag.2020.04.012
DO - 10.1016/j.clinimag.2020.04.012
M3 - Article
C2 - 32353719
AN - SCOPUS:85083722017
SN - 0899-7071
VL - 65
SP - 8
EP - 14
JO - Clinical Imaging
JF - Clinical Imaging
ER -