MRI features of intra-axial histiocytic brain mass lesions

L. P. Luna, A. Drier, N. Aygun, K. Mokhtari, K. Hoang-Xuan, D. Galanaud, J. Donadieu, D. Dormont, J. Haroche, N. Martin-Duverneuil

Research output: Contribution to journalArticlepeer-review

Abstract

AIM: To describe MRI features, including diffusion-weighted imaging (DWI), magnetic resonance spectroscopy (MRS), and perfusion-weighted imaging (PWI), of intra-axial tumour-like presentations of four different subtypes of histiocytosis. MATERIAL AND METHODS: The brain MRI findings of 23 patients with histologically proven histiocytosis were reviewed retrospectively (11 Langerhans cell histiocytosis [LCH], eight Erdheim–Chester disease [ECD], one overlap form LCH/ECD, two Rosai–Dorfman disease [RDD], and one haemophagocytic lymphohistiocytosis [HLH]) with single or multiple enhancing intraparenchymal brain lesions. RESULTS: Histiocytic brain mass lesions show some similar MRI features including Supra and/or infratentorial and/or paraventricular subcortical well-delineated masses, linear ependymal enhancement along the ventricles and brain stem lesions. Masses always present with mixed hyper- and hypointense signal on T2-weighted imaging (WI). Their enhancement is often homogeneous. Apparent diffusion coefficient (ADC) values are often normal or elevated. CONCLUSION: The presence of multiple periventricular and subcortical enhancing lesions with mixed signal intensity on T2WI and normal or high ADC values should lead radiologists to consider the diagnosis of histiocytic lesions and search for associated systemic lesions.

Original languageEnglish (US)
Pages (from-to)159.e19-159.e28
JournalClinical Radiology
Volume76
Issue number2
DOIs
StatePublished - Feb 2021

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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