MRI assisted motion correction in dual-gated 5D myocardial perfusion PET imaging

Jing Tang, Neal Hall, Arman Rahmim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Involuntary organ movement causes degradation in myocardial perfusion (MP) positron emission tomography (PET) imaging. Respiratory and/or cardiac gating reduces motion while lowering statistics in the reconstructed image frames. The advent of integrated PET/magnetic resonance imaging (MRI) provides opportunities for motion-compensated PET imaging using MRI measured motion. The purpose of this study is to correct respiratory and cardiac motion in dual-gated MP PET imaging, with non-rigid cardiac motion estimated from corresponding cardiac-gated MR images. Using the XCAT phantom, we simulated five-dimensional (5D) dual-gated PET data with and without MP defects and the corresponding 4D cardiac-gated MR images. For each cardiac gate, we performed integrated 4D respiratory motion-corrected image reconstruction to the respiratory-gated data, using the end-expiratory frame as the reference. Then we estimated cardiac motion from the gated MR images using an optical-flow determination algorithm. Using the cardiac motion fields, we warped and summed the respiratory motion-corrected cardiac-gated PET images with the end-diastolic frame as the reference. To evaluate the proposed technique, we performed receiver operating characteristic (ROC) analysis for MP defect detection using a channelized Hotelling observer. The ROC analysis resulted in an area under the curve (AUC) value of.96 ±.02 from images obtained using the proposed respiratory and cardiac motion compensation technique and an AUC value of.85 ±.04 from images reconstructed without motion correction. The proposed MRI assisted motion-corrected image reconstruction technique for dual-gated PET imaging is demonstrated to significantly improve the MP defect detection, which is promising for applications especially in emerging integrated PET/MRI.

Original languageEnglish (US)
Title of host publication2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012
Pages4054-4057
Number of pages4
DOIs
StatePublished - Dec 1 2012
Event2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012 - Anaheim, CA, United States
Duration: Oct 29 2012Nov 3 2012

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Other

Other2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012
CountryUnited States
CityAnaheim, CA
Period10/29/1211/3/12

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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