MRI and clinical activity in MS patients after terminating treatment with interferon beta-1b

Nancy D. Richert, Mary Christina Zierak, Craig N. Bash, Bobbi K. Lewis, Henry F. McFarland, Joseph A. Frank

Research output: Contribution to journalArticle

Abstract

Monthly MRI activity and clinical disability were evaluated in two relapsing-remitting multiple sclerosis (RRMS) patients for 4 years during a crossover treatment trial with IFNβ-1b, and for a mean of 21 months after terminating treatment with IFNβ-1b. Post-treatment MRI activity was compared to baseline activity in these patients. Although contrast enhancing lesions (CEL) and the bulk white matter lesion load (BWMLL) on T2-weighted images eventually returned to baseline values, there was a refractory period of 6 - 10 months after terminating treatment, before baseline MRI activity was restored. Although the mechanism for a sustained effect of IFNβ-1b is unclear at this time, these results have important implications for enrollment of such patients into new treatment protocols that rely on contrast enhancing lesion frequency as an outcome measure.

Original languageEnglish (US)
Pages (from-to)86-90
Number of pages5
JournalMultiple Sclerosis
Volume6
Issue number2
Publication statusPublished - Apr 2000
Externally publishedYes

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Keywords

  • Interferon beta-1b
  • Magnetic resonance imaging
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Richert, N. D., Zierak, M. C., Bash, C. N., Lewis, B. K., McFarland, H. F., & Frank, J. A. (2000). MRI and clinical activity in MS patients after terminating treatment with interferon beta-1b. Multiple Sclerosis, 6(2), 86-90.