Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness

Liang Han; Nathachit Limjunyawong; Fei Ru; Zhe Li; Olivia J. Hall; Haley Steele; Yuyan Zhu; Julie Wilson; Wayne Mitzner; Marian Kollarik; Bradley J. Undem; Brendan J. Canning; Xinzhong Dong

doi:10.1038/s41593-018-0074-8

Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness

Liang Han, Nathachit Limjunyawong, Fei Ru, Zhe Li, Olivia J. Hall, Haley Steele, Yuyan Zhu, Julie Wilson, Wayne Mitzner, Marian Kollarik, Bradley J. Undem, Brendan J. Canning, Xinzhong Dong

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Asthma, accompanied by lung inflammation, bronchoconstriction and airway hyper-responsiveness, is a significant public health burden. Here we report that Mas-related G protein-coupled receptors (Mrgprs) are expressed in a subset of vagal sensory neurons innervating the airway and mediates cholinergic bronchoconstriction and airway hyper-responsiveness. These findings provide insights into the neural mechanisms underlying the pathogenesis of asthma.

Original language	English (US)
Pages (from-to)	324-328
Number of pages	5
Journal	Nature neuroscience
Volume	21
Issue number	3
DOIs	https://doi.org/10.1038/s41593-018-0074-8
State	Published - Mar 1 2018

ASJC Scopus subject areas

General Neuroscience

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title = "Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness",

abstract = "Asthma, accompanied by lung inflammation, bronchoconstriction and airway hyper-responsiveness, is a significant public health burden. Here we report that Mas-related G protein-coupled receptors (Mrgprs) are expressed in a subset of vagal sensory neurons innervating the airway and mediates cholinergic bronchoconstriction and airway hyper-responsiveness. These findings provide insights into the neural mechanisms underlying the pathogenesis of asthma.",

author = "Liang Han and Nathachit Limjunyawong and Fei Ru and Zhe Li and Hall, {Olivia J.} and Haley Steele and Yuyan Zhu and Julie Wilson and Wayne Mitzner and Marian Kollarik and Undem, {Bradley J.} and Canning, {Brendan J.} and Xinzhong Dong",

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T1 - Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness

AU - Han, Liang

AU - Limjunyawong, Nathachit

AU - Ru, Fei

AU - Li, Zhe

AU - Hall, Olivia J.

AU - Steele, Haley

AU - Zhu, Yuyan

AU - Wilson, Julie

AU - Mitzner, Wayne

AU - Kollarik, Marian

AU - Undem, Bradley J.

AU - Canning, Brendan J.

AU - Dong, Xinzhong

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Asthma, accompanied by lung inflammation, bronchoconstriction and airway hyper-responsiveness, is a significant public health burden. Here we report that Mas-related G protein-coupled receptors (Mrgprs) are expressed in a subset of vagal sensory neurons innervating the airway and mediates cholinergic bronchoconstriction and airway hyper-responsiveness. These findings provide insights into the neural mechanisms underlying the pathogenesis of asthma.

AB - Asthma, accompanied by lung inflammation, bronchoconstriction and airway hyper-responsiveness, is a significant public health burden. Here we report that Mas-related G protein-coupled receptors (Mrgprs) are expressed in a subset of vagal sensory neurons innervating the airway and mediates cholinergic bronchoconstriction and airway hyper-responsiveness. These findings provide insights into the neural mechanisms underlying the pathogenesis of asthma.

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Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness

Abstract

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