MR spectroscopy study of dichloroacetate treatment after ischemic stroke

Glenn D. Graham, P. B. Barker, W. M. Brooks, D. C. Morris, W. Ahmed, E. Bryniarski, D. O. Hearshen, J. A. Sanders, B. A. Holshouser, C. C. Turkel

Research output: Contribution to journalArticle

Abstract

In a double-blind, placebo-controlled study, we used 1H MR spectroscopy to assess the effect of a single infusion of sodium dichloroacetate on lesion lactate 1 to 5 days after ischemic stroke. Apparent trends toward a reduction in lactate/N-acetyl compound ratios were seen at the higher drug doses employed, and in patients treated in the first 2 days following infarction. Use of spectroscopic measures as endpoints is feasible in acute stroke clinical trials.

Original languageEnglish (US)
Pages (from-to)1376-1378
Number of pages3
JournalNeurology
Volume55
Issue number9
StatePublished - Nov 14 2000
Externally publishedYes

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ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Graham, G. D., Barker, P. B., Brooks, W. M., Morris, D. C., Ahmed, W., Bryniarski, E., Hearshen, D. O., Sanders, J. A., Holshouser, B. A., & Turkel, C. C. (2000). MR spectroscopy study of dichloroacetate treatment after ischemic stroke. Neurology, 55(9), 1376-1378.