MR spectroscopy study of dichloroacetate treatment after ischemic stroke

Glenn D. Graham, Peter B Barker, W. M. Brooks, D. C. Morris, W. Ahmed, E. Bryniarski, D. O. Hearshen, J. A. Sanders, B. A. Holshouser, C. C. Turkel

Research output: Contribution to journalArticle

Abstract

In a double-blind, placebo-controlled study, we used 1H MR spectroscopy to assess the effect of a single infusion of sodium dichloroacetate on lesion lactate 1 to 5 days after ischemic stroke. Apparent trends toward a reduction in lactate/N-acetyl compound ratios were seen at the higher drug doses employed, and in patients treated in the first 2 days following infarction. Use of spectroscopic measures as endpoints is feasible in acute stroke clinical trials.

Original languageEnglish (US)
Pages (from-to)1376-1378
Number of pages3
JournalNeurology
Volume55
Issue number9
StatePublished - Nov 14 2000
Externally publishedYes

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Lactic Acid
Magnetic Resonance Spectroscopy
Dichloroacetic Acid
Stroke
Infarction
Placebos
Clinical Trials
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Graham, G. D., Barker, P. B., Brooks, W. M., Morris, D. C., Ahmed, W., Bryniarski, E., ... Turkel, C. C. (2000). MR spectroscopy study of dichloroacetate treatment after ischemic stroke. Neurology, 55(9), 1376-1378.

MR spectroscopy study of dichloroacetate treatment after ischemic stroke. / Graham, Glenn D.; Barker, Peter B; Brooks, W. M.; Morris, D. C.; Ahmed, W.; Bryniarski, E.; Hearshen, D. O.; Sanders, J. A.; Holshouser, B. A.; Turkel, C. C.

In: Neurology, Vol. 55, No. 9, 14.11.2000, p. 1376-1378.

Research output: Contribution to journalArticle

Graham, GD, Barker, PB, Brooks, WM, Morris, DC, Ahmed, W, Bryniarski, E, Hearshen, DO, Sanders, JA, Holshouser, BA & Turkel, CC 2000, 'MR spectroscopy study of dichloroacetate treatment after ischemic stroke', Neurology, vol. 55, no. 9, pp. 1376-1378.
Graham GD, Barker PB, Brooks WM, Morris DC, Ahmed W, Bryniarski E et al. MR spectroscopy study of dichloroacetate treatment after ischemic stroke. Neurology. 2000 Nov 14;55(9):1376-1378.
Graham, Glenn D. ; Barker, Peter B ; Brooks, W. M. ; Morris, D. C. ; Ahmed, W. ; Bryniarski, E. ; Hearshen, D. O. ; Sanders, J. A. ; Holshouser, B. A. ; Turkel, C. C. / MR spectroscopy study of dichloroacetate treatment after ischemic stroke. In: Neurology. 2000 ; Vol. 55, No. 9. pp. 1376-1378.
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