MR proton spectroscopy for myocardial lipid deposition quantification

A quantitative comparison between 1.5T and 3T

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate 3T magnetic resonance spectroscopy (MRS)-derived myocardial fat-signal fractions in comparison with those from 1.5T MRS. Materials and Methods: We conducted phantom, ex vivo and in vivo myocardial specimen evaluations at both 1.5T and 3T using 1H-MRS. A phantom with nine fat-water emulsions was constructed to assess the accuracy of the spectroscopy measurements. Ex vivo spectroscopy data were acquired in 70 segments from 21 autopsy heart slices. In vivo spectroscopy data were acquired in the interventricular septum from 22 human volunteers. Results: Phantom experiments demonstrated that 1.5T and 3T measurements were highly correlated with the reference values (r = 0.78, P <0.05). The ex vivo and in vivo experiments demonstrated an increase in signal-to-noise ratio (SNR) of 45 ± 73% and 76 ± 72% at 3T compared to 1.5T (P <0.05). The mean fat-signal fraction was similar at 3T and 1.5T (1.11 ± 1.18 vs. 1.00 ± 1.09, respectively, P = NS) in ex vivo studies but were significantly different in the in vivo studies (2.47 ± 1.46 vs. 1.56 ± 1.34, P <0.05). The fat-signal fractions from 3T and 1.5T correlated fairly well in all experiments. Conclusion: 3T MRS has significantly greater SNR and could potentially be more accurate as compared to 1.5T for quantification of myocardial fat fraction in in vivo studies.

Original languageEnglish (US)
Pages (from-to)1222-1230
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume36
Issue number5
DOIs
StatePublished - Nov 2012

Fingerprint

Protons
Magnetic Resonance Spectroscopy
Fats
Lipids
Spectrum Analysis
Signal-To-Noise Ratio
Emulsions
Volunteers
Autopsy
Reference Values
Water

Keywords

  • fat fraction
  • myocardial fat
  • proton spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{34ab08d9949d4f6ca33e3d4a0f24420c,
title = "MR proton spectroscopy for myocardial lipid deposition quantification: A quantitative comparison between 1.5T and 3T",
abstract = "Purpose: To evaluate 3T magnetic resonance spectroscopy (MRS)-derived myocardial fat-signal fractions in comparison with those from 1.5T MRS. Materials and Methods: We conducted phantom, ex vivo and in vivo myocardial specimen evaluations at both 1.5T and 3T using 1H-MRS. A phantom with nine fat-water emulsions was constructed to assess the accuracy of the spectroscopy measurements. Ex vivo spectroscopy data were acquired in 70 segments from 21 autopsy heart slices. In vivo spectroscopy data were acquired in the interventricular septum from 22 human volunteers. Results: Phantom experiments demonstrated that 1.5T and 3T measurements were highly correlated with the reference values (r = 0.78, P <0.05). The ex vivo and in vivo experiments demonstrated an increase in signal-to-noise ratio (SNR) of 45 ± 73{\%} and 76 ± 72{\%} at 3T compared to 1.5T (P <0.05). The mean fat-signal fraction was similar at 3T and 1.5T (1.11 ± 1.18 vs. 1.00 ± 1.09, respectively, P = NS) in ex vivo studies but were significantly different in the in vivo studies (2.47 ± 1.46 vs. 1.56 ± 1.34, P <0.05). The fat-signal fractions from 3T and 1.5T correlated fairly well in all experiments. Conclusion: 3T MRS has significantly greater SNR and could potentially be more accurate as compared to 1.5T for quantification of myocardial fat fraction in in vivo studies.",
keywords = "fat fraction, myocardial fat, proton spectroscopy",
author = "{Ambale Venkatesh}, Bharath and Joao Lima and Bluemke, {David A.} and Shenghan Lai and Steenbergen, {Charles Jr} and Liu, {Chia Ying}",
year = "2012",
month = "11",
doi = "10.1002/jmri.23761",
language = "English (US)",
volume = "36",
pages = "1222--1230",
journal = "Journal of Magnetic Resonance Imaging",
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}

TY - JOUR

T1 - MR proton spectroscopy for myocardial lipid deposition quantification

T2 - A quantitative comparison between 1.5T and 3T

AU - Ambale Venkatesh, Bharath

AU - Lima, Joao

AU - Bluemke, David A.

AU - Lai, Shenghan

AU - Steenbergen, Charles Jr

AU - Liu, Chia Ying

PY - 2012/11

Y1 - 2012/11

N2 - Purpose: To evaluate 3T magnetic resonance spectroscopy (MRS)-derived myocardial fat-signal fractions in comparison with those from 1.5T MRS. Materials and Methods: We conducted phantom, ex vivo and in vivo myocardial specimen evaluations at both 1.5T and 3T using 1H-MRS. A phantom with nine fat-water emulsions was constructed to assess the accuracy of the spectroscopy measurements. Ex vivo spectroscopy data were acquired in 70 segments from 21 autopsy heart slices. In vivo spectroscopy data were acquired in the interventricular septum from 22 human volunteers. Results: Phantom experiments demonstrated that 1.5T and 3T measurements were highly correlated with the reference values (r = 0.78, P <0.05). The ex vivo and in vivo experiments demonstrated an increase in signal-to-noise ratio (SNR) of 45 ± 73% and 76 ± 72% at 3T compared to 1.5T (P <0.05). The mean fat-signal fraction was similar at 3T and 1.5T (1.11 ± 1.18 vs. 1.00 ± 1.09, respectively, P = NS) in ex vivo studies but were significantly different in the in vivo studies (2.47 ± 1.46 vs. 1.56 ± 1.34, P <0.05). The fat-signal fractions from 3T and 1.5T correlated fairly well in all experiments. Conclusion: 3T MRS has significantly greater SNR and could potentially be more accurate as compared to 1.5T for quantification of myocardial fat fraction in in vivo studies.

AB - Purpose: To evaluate 3T magnetic resonance spectroscopy (MRS)-derived myocardial fat-signal fractions in comparison with those from 1.5T MRS. Materials and Methods: We conducted phantom, ex vivo and in vivo myocardial specimen evaluations at both 1.5T and 3T using 1H-MRS. A phantom with nine fat-water emulsions was constructed to assess the accuracy of the spectroscopy measurements. Ex vivo spectroscopy data were acquired in 70 segments from 21 autopsy heart slices. In vivo spectroscopy data were acquired in the interventricular septum from 22 human volunteers. Results: Phantom experiments demonstrated that 1.5T and 3T measurements were highly correlated with the reference values (r = 0.78, P <0.05). The ex vivo and in vivo experiments demonstrated an increase in signal-to-noise ratio (SNR) of 45 ± 73% and 76 ± 72% at 3T compared to 1.5T (P <0.05). The mean fat-signal fraction was similar at 3T and 1.5T (1.11 ± 1.18 vs. 1.00 ± 1.09, respectively, P = NS) in ex vivo studies but were significantly different in the in vivo studies (2.47 ± 1.46 vs. 1.56 ± 1.34, P <0.05). The fat-signal fractions from 3T and 1.5T correlated fairly well in all experiments. Conclusion: 3T MRS has significantly greater SNR and could potentially be more accurate as compared to 1.5T for quantification of myocardial fat fraction in in vivo studies.

KW - fat fraction

KW - myocardial fat

KW - proton spectroscopy

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