MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain

Jeff W.M. Bulte, Tamir Ben-Hur, Bradley R. Miller, Rachel Mizrachi-Kol, Ophira Einstein, Etti Reinhartz, Holly A. Zywicke, Trevor Douglas, Joseph A. Frank

Research output: Contribution to journalArticle

Abstract

Stem cell transplantation is being explored as a new paradigm for the treatment of demyelinating diseases. Magnetically labeled multipotential neural precursor cells were transplanted into the ventricles of rats with acute experimental allergic encephalomyelitis (EAE) and high-resolution (microscopic) MR images were obtained ex vivo. Migration patterns of live cells into periventricular white matter structures could be easily visualized, with a good correlation of the corresponding histopathology. The present results confirm that MR cell tracking can be used to guide the development of successful transplantation protocols.

Original languageEnglish (US)
Pages (from-to)201-205
Number of pages5
JournalMagnetic resonance in medicine
Volume50
Issue number1
DOIs
StatePublished - Jul 1 2003

Keywords

  • Experimental autoimmune encephalomyelitis
  • Iron oxide MR contrast agent
  • MR microscopy
  • Neurospheres
  • Transplantation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Bulte, J. W. M., Ben-Hur, T., Miller, B. R., Mizrachi-Kol, R., Einstein, O., Reinhartz, E., Zywicke, H. A., Douglas, T., & Frank, J. A. (2003). MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain. Magnetic resonance in medicine, 50(1), 201-205. https://doi.org/10.1002/mrm.10511