MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain

Jeff W.M. Bulte; Tamir Ben-Hur; Bradley R. Miller; Rachel Mizrachi-Kol; Ophira Einstein; Etti Reinhartz; Holly A. Zywicke; Trevor Douglas; Joseph A. Frank

doi:10.1002/mrm.10511

MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain

Jeff W.M. Bulte, Tamir Ben-Hur, Bradley R. Miller, Rachel Mizrachi-Kol, Ophira Einstein, Etti Reinhartz, Holly A. Zywicke, Trevor Douglas, Joseph A. Frank

School of Medicine

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

Stem cell transplantation is being explored as a new paradigm for the treatment of demyelinating diseases. Magnetically labeled multipotential neural precursor cells were transplanted into the ventricles of rats with acute experimental allergic encephalomyelitis (EAE) and high-resolution (microscopic) MR images were obtained ex vivo. Migration patterns of live cells into periventricular white matter structures could be easily visualized, with a good correlation of the corresponding histopathology. The present results confirm that MR cell tracking can be used to guide the development of successful transplantation protocols.

Original language	English (US)
Pages (from-to)	201-205
Number of pages	5
Journal	Magnetic resonance in medicine
Volume	50
Issue number	1
DOIs	https://doi.org/10.1002/mrm.10511
State	Published - Jul 1 2003

Keywords

Experimental autoimmune encephalomyelitis
Iron oxide MR contrast agent
MR microscopy
Neurospheres
Transplantation

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/mrm.10511

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abstract = "Stem cell transplantation is being explored as a new paradigm for the treatment of demyelinating diseases. Magnetically labeled multipotential neural precursor cells were transplanted into the ventricles of rats with acute experimental allergic encephalomyelitis (EAE) and high-resolution (microscopic) MR images were obtained ex vivo. Migration patterns of live cells into periventricular white matter structures could be easily visualized, with a good correlation of the corresponding histopathology. The present results confirm that MR cell tracking can be used to guide the development of successful transplantation protocols.",

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AU - Bulte, Jeff W.M.

AU - Ben-Hur, Tamir

AU - Miller, Bradley R.

AU - Mizrachi-Kol, Rachel

AU - Einstein, Ophira

AU - Reinhartz, Etti

AU - Zywicke, Holly A.

AU - Douglas, Trevor

AU - Frank, Joseph A.

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AB - Stem cell transplantation is being explored as a new paradigm for the treatment of demyelinating diseases. Magnetically labeled multipotential neural precursor cells were transplanted into the ventricles of rats with acute experimental allergic encephalomyelitis (EAE) and high-resolution (microscopic) MR images were obtained ex vivo. Migration patterns of live cells into periventricular white matter structures could be easily visualized, with a good correlation of the corresponding histopathology. The present results confirm that MR cell tracking can be used to guide the development of successful transplantation protocols.

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KW - Iron oxide MR contrast agent

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KW - Neurospheres

KW - Transplantation

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MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain

Abstract

Keywords

ASJC Scopus subject areas

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