Abstract
The purpose of our study was the application and validation of a phase-sensitive pulse sequence that allowed real time CSF flow measurement without need for electrocardiographic (ECG) synchronization. After excitation of a slice perpendicular to the axis of the spine, projective data were obtained with a gradient echo sequence [contrast enhanced Fourier acquired steady- state technique (CE-FAST)] without spin warp gradient [real time acquisition and evaluation of motion technique (RACE)], allowing one-dimensional spatial resolution across the region of interest with a total sampling time of 20-30 ms. The sequence was calibrated with a spinal CSF phantom with oscillatory fluid motion. The calculated mean pulsation amplitudes of 20 healthy volunteers in the cervical region were 16 mm (range 9-36 mm), in the thoracic region 11 mm (5-21 mm), and in the lumbar region 3 mm (1-6 mm). The technique was capable of demonstrating physiologic alterations of CSF flow during respiratory maneuvers and may provide a tool to evaluate the altered CSF dynamics resulting from spinal block, inflammatory processes, or hemorrhage.
Original language | English (US) |
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Pages (from-to) | 54-61 |
Number of pages | 8 |
Journal | Journal of computer assisted tomography |
Volume | 16 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1992 |
Externally published | Yes |
Keywords
- Cerebrospinal fluid flow
- Magnetic resonance imaging techniques
- Real time acquisition and evaluation of motion technique (RACE)
- Spine
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging