MR imaging of transplanted stem cells in myocardial infarction.

Research output: Contribution to journalArticle

Abstract

Recently, several protocols for labeling of stem cells with superparamagnetic iron oxides (SPIOs) have been developed, leading to an active and growing field aimed at visualizing stem cells using MRI (magnetic resonance imaging), including image-guided stem cell injections. This development occurred simultaneously with a significant rise in the number of cell therapy clinical trials for cardiovascular applications and their preceding pre-clinical studies in animal models. In this chapter, we will describe several labeling strategies that can be used to label cells with SPIO nanoparticles. This is followed by a discussion of current strategies for using MRI to visualize these cells in myocardial infarct.

Original languageEnglish (US)
Pages (from-to)141-152
Number of pages12
JournalMethods in molecular biology (Clifton, N.J.)
Volume680
StatePublished - 2011

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Stem Cells
Myocardial Infarction
Magnetic Resonance Imaging
Cell- and Tissue-Based Therapy
Nanoparticles
Animal Models
Clinical Trials
Injections
ferric oxide
Clinical Studies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

MR imaging of transplanted stem cells in myocardial infarction. / Kraitchman, Dara L.; Kedziorek, Dorota; Bulte, Jeff W M.

In: Methods in molecular biology (Clifton, N.J.), Vol. 680, 2011, p. 141-152.

Research output: Contribution to journalArticle

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