MR imaging of human brain at 3.0 T: Preliminary report on transverse relaxation rates and relation to estimated iron content

Nell Gelman, Jay M. Gorell, Peter B Barker, Ralph M. Savage, Eric M. Spickler, Joseph P. Windham, Robert A. Knight

Research output: Contribution to journalArticle

Abstract

PURPOSE: To determine the transverse relaxation rates R2 and R2' from several gray matter regions and from frontal cortical white matter in healthy human brains in vivo and to determine the relationship between relaxation rates and iron concentration [Fe]. MATERIALS AND METHODS: Six healthy adults aged 19-42 years underwent thin-section gradient-echo sampling of free induction decay and echo magnetic resonance (MR) imaging at 3.0 T. Imaging covered the mesencephalon and basal ganglia. RESULTS: Relaxation rates (mean ± SD) were highest in globus pallidus (R2 = 25.8 seconds-1 ± 1.1, R2' = 12.0 seconds-1 ± 2.1) and lowest in prefrontal cortex (R2 14.4 seconds- 1 ± 1.8, R2' = 3.4 seconds-1 ± 1.1). Frontal white matter measurements were as follows: R2 = 18.0 seconds-1 ± 1.2 and R2' = 3.9 seconds-1 ± 1.2. For gray matter, both R2 and R2' showed a strong correlation (r = 0.92, P <.001 and r = 0.90, P <.001, respectively) with [Fe]. Although the slopes of the regression lines for R2' versus [Fe] and for R2 versus [Fe] were similar, the iron-independent component of R2' (2.2 seconds-1 ± 0.6), the value when [Fe] = 0, was much less than that of R2 (12.7 seconds-1 ± 0.7). CONCLUSION: The small iron-independent component of R2', as compared with that of R2, is consistent with the hypothesis that R2' has higher iron- related specificity.

Original languageEnglish (US)
Pages (from-to)759-767
Number of pages9
JournalRadiology
Volume210
Issue number3
StatePublished - Mar 1999

Fingerprint

Iron
Magnetic Resonance Imaging
Brain
Globus Pallidus
Mesencephalon
Basal Ganglia
Prefrontal Cortex
White Matter
Gray Matter

Keywords

  • Brain, iron
  • Brain, MR
  • Iron
  • Magnetic resonance (MR), high-field-strength imaging
  • Magnetic resonance (MR), relaxometry

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Gelman, N., Gorell, J. M., Barker, P. B., Savage, R. M., Spickler, E. M., Windham, J. P., & Knight, R. A. (1999). MR imaging of human brain at 3.0 T: Preliminary report on transverse relaxation rates and relation to estimated iron content. Radiology, 210(3), 759-767.

MR imaging of human brain at 3.0 T : Preliminary report on transverse relaxation rates and relation to estimated iron content. / Gelman, Nell; Gorell, Jay M.; Barker, Peter B; Savage, Ralph M.; Spickler, Eric M.; Windham, Joseph P.; Knight, Robert A.

In: Radiology, Vol. 210, No. 3, 03.1999, p. 759-767.

Research output: Contribution to journalArticle

Gelman, N, Gorell, JM, Barker, PB, Savage, RM, Spickler, EM, Windham, JP & Knight, RA 1999, 'MR imaging of human brain at 3.0 T: Preliminary report on transverse relaxation rates and relation to estimated iron content', Radiology, vol. 210, no. 3, pp. 759-767.
Gelman, Nell ; Gorell, Jay M. ; Barker, Peter B ; Savage, Ralph M. ; Spickler, Eric M. ; Windham, Joseph P. ; Knight, Robert A. / MR imaging of human brain at 3.0 T : Preliminary report on transverse relaxation rates and relation to estimated iron content. In: Radiology. 1999 ; Vol. 210, No. 3. pp. 759-767.
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abstract = "PURPOSE: To determine the transverse relaxation rates R2 and R2' from several gray matter regions and from frontal cortical white matter in healthy human brains in vivo and to determine the relationship between relaxation rates and iron concentration [Fe]. MATERIALS AND METHODS: Six healthy adults aged 19-42 years underwent thin-section gradient-echo sampling of free induction decay and echo magnetic resonance (MR) imaging at 3.0 T. Imaging covered the mesencephalon and basal ganglia. RESULTS: Relaxation rates (mean ± SD) were highest in globus pallidus (R2 = 25.8 seconds-1 ± 1.1, R2' = 12.0 seconds-1 ± 2.1) and lowest in prefrontal cortex (R2 14.4 seconds- 1 ± 1.8, R2' = 3.4 seconds-1 ± 1.1). Frontal white matter measurements were as follows: R2 = 18.0 seconds-1 ± 1.2 and R2' = 3.9 seconds-1 ± 1.2. For gray matter, both R2 and R2' showed a strong correlation (r = 0.92, P <.001 and r = 0.90, P <.001, respectively) with [Fe]. Although the slopes of the regression lines for R2' versus [Fe] and for R2 versus [Fe] were similar, the iron-independent component of R2' (2.2 seconds-1 ± 0.6), the value when [Fe] = 0, was much less than that of R2 (12.7 seconds-1 ± 0.7). CONCLUSION: The small iron-independent component of R2', as compared with that of R2, is consistent with the hypothesis that R2' has higher iron- related specificity.",
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AU - Gelman, Nell

AU - Gorell, Jay M.

AU - Barker, Peter B

AU - Savage, Ralph M.

AU - Spickler, Eric M.

AU - Windham, Joseph P.

AU - Knight, Robert A.

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N2 - PURPOSE: To determine the transverse relaxation rates R2 and R2' from several gray matter regions and from frontal cortical white matter in healthy human brains in vivo and to determine the relationship between relaxation rates and iron concentration [Fe]. MATERIALS AND METHODS: Six healthy adults aged 19-42 years underwent thin-section gradient-echo sampling of free induction decay and echo magnetic resonance (MR) imaging at 3.0 T. Imaging covered the mesencephalon and basal ganglia. RESULTS: Relaxation rates (mean ± SD) were highest in globus pallidus (R2 = 25.8 seconds-1 ± 1.1, R2' = 12.0 seconds-1 ± 2.1) and lowest in prefrontal cortex (R2 14.4 seconds- 1 ± 1.8, R2' = 3.4 seconds-1 ± 1.1). Frontal white matter measurements were as follows: R2 = 18.0 seconds-1 ± 1.2 and R2' = 3.9 seconds-1 ± 1.2. For gray matter, both R2 and R2' showed a strong correlation (r = 0.92, P <.001 and r = 0.90, P <.001, respectively) with [Fe]. Although the slopes of the regression lines for R2' versus [Fe] and for R2 versus [Fe] were similar, the iron-independent component of R2' (2.2 seconds-1 ± 0.6), the value when [Fe] = 0, was much less than that of R2 (12.7 seconds-1 ± 0.7). CONCLUSION: The small iron-independent component of R2', as compared with that of R2, is consistent with the hypothesis that R2' has higher iron- related specificity.

AB - PURPOSE: To determine the transverse relaxation rates R2 and R2' from several gray matter regions and from frontal cortical white matter in healthy human brains in vivo and to determine the relationship between relaxation rates and iron concentration [Fe]. MATERIALS AND METHODS: Six healthy adults aged 19-42 years underwent thin-section gradient-echo sampling of free induction decay and echo magnetic resonance (MR) imaging at 3.0 T. Imaging covered the mesencephalon and basal ganglia. RESULTS: Relaxation rates (mean ± SD) were highest in globus pallidus (R2 = 25.8 seconds-1 ± 1.1, R2' = 12.0 seconds-1 ± 2.1) and lowest in prefrontal cortex (R2 14.4 seconds- 1 ± 1.8, R2' = 3.4 seconds-1 ± 1.1). Frontal white matter measurements were as follows: R2 = 18.0 seconds-1 ± 1.2 and R2' = 3.9 seconds-1 ± 1.2. For gray matter, both R2 and R2' showed a strong correlation (r = 0.92, P <.001 and r = 0.90, P <.001, respectively) with [Fe]. Although the slopes of the regression lines for R2' versus [Fe] and for R2 versus [Fe] were similar, the iron-independent component of R2' (2.2 seconds-1 ± 0.6), the value when [Fe] = 0, was much less than that of R2 (12.7 seconds-1 ± 0.7). CONCLUSION: The small iron-independent component of R2', as compared with that of R2, is consistent with the hypothesis that R2' has higher iron- related specificity.

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