Mr imaging of cerebral perfusion by phase‐angle reconstruction of bolus paramagnetic‐induced frequency shifts

Thomas E. Conturo, Peter B. Barker, Vincent P. Mathews, Lee H. Monsein, R. Nick Bryan

Research output: Contribution to journalArticlepeer-review

Abstract

Phase‐angle images are acquired dynamically during bouls paramagnetic contrast injection and demonstrate a phase‐enhancement effect in perfused cerebral tissues. Signal‐to‐noise is comparable to that of susceptibility‐based signal loss (ΔR) images. Assuming that phase shift is proportional to the tissue paramagnetic agent concentration, as supported by experimental data, the integrated area of the phase time response curves estimated the relative gray to white matter blood volume as 1.8:1 and was sensitive to acute ischemia. The relation between tissue phase shift and concentration is considered.

Original languageEnglish (US)
Pages (from-to)375-390
Number of pages16
JournalMagnetic resonance in medicine
Volume27
Issue number2
DOIs
StatePublished - Oct 1992

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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