MR imaging of cerebral perfusion by phase-angle reconstruction of bolus paramagnetic-induced frequency shifts

T. E. Conturo, Peter B Barker, V. P. Mathews, L. H. Monsein, R. N. Bryan

Research output: Contribution to journalArticle

Abstract

Phase-angle images are acquired dynamically during bolus paramagnetic contrast injection and demonstrate a phase-enhancement effect in perfused cerebral tissues. Signal-to-noise is comparable to that of susceptibility- based signal loss (ΔR*) images. Assuming that phase shift is proportional to the tissue paramagnetic agent concentration, as supported by experimental data, the integrated area of the phase time response curves estimated the relative gray to white matter blood volume as 1.8:1 and was sensitive to acute ischemia. The relation between tissue phase shift and concentration is considered.

Original languageEnglish (US)
Pages (from-to)375-390
Number of pages16
JournalMagnetic Resonance in Medicine
Volume27
Issue number2
DOIs
StatePublished - 1992

Fingerprint

Perfusion Imaging
Blood Volume
Noise
Ischemia
Injections

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

MR imaging of cerebral perfusion by phase-angle reconstruction of bolus paramagnetic-induced frequency shifts. / Conturo, T. E.; Barker, Peter B; Mathews, V. P.; Monsein, L. H.; Bryan, R. N.

In: Magnetic Resonance in Medicine, Vol. 27, No. 2, 1992, p. 375-390.

Research output: Contribution to journalArticle

Conturo, T. E. ; Barker, Peter B ; Mathews, V. P. ; Monsein, L. H. ; Bryan, R. N. / MR imaging of cerebral perfusion by phase-angle reconstruction of bolus paramagnetic-induced frequency shifts. In: Magnetic Resonance in Medicine. 1992 ; Vol. 27, No. 2. pp. 375-390.
@article{44fbb987b27b4cfe94167ffa57ad13ec,
title = "MR imaging of cerebral perfusion by phase-angle reconstruction of bolus paramagnetic-induced frequency shifts",
abstract = "Phase-angle images are acquired dynamically during bolus paramagnetic contrast injection and demonstrate a phase-enhancement effect in perfused cerebral tissues. Signal-to-noise is comparable to that of susceptibility- based signal loss (ΔR*) images. Assuming that phase shift is proportional to the tissue paramagnetic agent concentration, as supported by experimental data, the integrated area of the phase time response curves estimated the relative gray to white matter blood volume as 1.8:1 and was sensitive to acute ischemia. The relation between tissue phase shift and concentration is considered.",
author = "Conturo, {T. E.} and Barker, {Peter B} and Mathews, {V. P.} and Monsein, {L. H.} and Bryan, {R. N.}",
year = "1992",
doi = "10.1002/mrm.1910270219",
language = "English (US)",
volume = "27",
pages = "375--390",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - MR imaging of cerebral perfusion by phase-angle reconstruction of bolus paramagnetic-induced frequency shifts

AU - Conturo, T. E.

AU - Barker, Peter B

AU - Mathews, V. P.

AU - Monsein, L. H.

AU - Bryan, R. N.

PY - 1992

Y1 - 1992

N2 - Phase-angle images are acquired dynamically during bolus paramagnetic contrast injection and demonstrate a phase-enhancement effect in perfused cerebral tissues. Signal-to-noise is comparable to that of susceptibility- based signal loss (ΔR*) images. Assuming that phase shift is proportional to the tissue paramagnetic agent concentration, as supported by experimental data, the integrated area of the phase time response curves estimated the relative gray to white matter blood volume as 1.8:1 and was sensitive to acute ischemia. The relation between tissue phase shift and concentration is considered.

AB - Phase-angle images are acquired dynamically during bolus paramagnetic contrast injection and demonstrate a phase-enhancement effect in perfused cerebral tissues. Signal-to-noise is comparable to that of susceptibility- based signal loss (ΔR*) images. Assuming that phase shift is proportional to the tissue paramagnetic agent concentration, as supported by experimental data, the integrated area of the phase time response curves estimated the relative gray to white matter blood volume as 1.8:1 and was sensitive to acute ischemia. The relation between tissue phase shift and concentration is considered.

UR - http://www.scopus.com/inward/record.url?scp=0026793051&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026793051&partnerID=8YFLogxK

U2 - 10.1002/mrm.1910270219

DO - 10.1002/mrm.1910270219

M3 - Article

VL - 27

SP - 375

EP - 390

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 2

ER -