MR imaging in adenocarcinoma of the prostate: Interobserver variation and efficacy for determining stage C disease

M. L. Schiebler, B. C. Yankaskas, C. Tempany, C. E. Spritzer, M. D. Rifkin, H. M. Pollack, P. Holtz, Elias Zerhouni

Research output: Contribution to journalArticle

Abstract

Patients with adenocarcinoma of the prostate confined to the gland (stage B) are candidates for a potentially curative surgical procedure (radical retropubic prostatectomy). However, patients with adenocarcinoma that penetrates the capsule or invades the seminal vesicles (stage C) are no longer considered good candidates for surgical cure of their disease. The purpose of this study was to compare the ability of four radiologists to detect stage C disease on MR images and to evaluate interobserver variability. One hundred consecutive MR studies of the prostate were reviewed independently by four radiologists to determine whether the cancer was stage C (capsule penetration or seminal vesicle invasion by tumor). A radical prostatectomy was performed in each case, and careful histologic assessment was made of the prostatic capsule and seminal vesicles for any evidence of stage C disease. The sensitivity, specificity, and accuracy (true-positive + true-negative/100 patients) in detecting stage C disease were calculated for each of the four readers. Four receiver-operating-characteristic curves were generated and compared by means of the univariate z score. Percentage agreement was calculated for five specific areas of the prostate on MR images, and observations made by the best reader were compared with the other three to help determine interreader variability. The results showed that the sensitivity and specificity of MR imaging in detecting stage C disease ranged from .24 to .61 (mean, .48) and .49 to .79 (mean, .66), respectively. The accuracy of MR imaging ranged from .47 to .61 (mean, .55). The univariate z score test showed that one of the readers significantly differed from the other three. The average percentage agreement between that reader and the other three was 70% for the five separate anatomic regions. This study shows that considerable interobserver variation exists in the interpretation of MR images for staging cancer of the prostate. The average accuracy among four radiologists in determining the presence of stage C adenocarcinoma of the prostate from MR images was only slightly above a chance guess at .55.

Original languageEnglish (US)
Pages (from-to)559-562
Number of pages4
JournalAmerican Journal of Roentgenology
Volume158
Issue number3
StatePublished - 1992
Externally publishedYes

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Observer Variation
Prostate
Adenocarcinoma
Seminal Vesicles
Capsules
Prostatectomy
Sensitivity and Specificity
ROC Curve
Neoplasms
Prostatic Neoplasms
Radiologists

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Schiebler, M. L., Yankaskas, B. C., Tempany, C., Spritzer, C. E., Rifkin, M. D., Pollack, H. M., ... Zerhouni, E. (1992). MR imaging in adenocarcinoma of the prostate: Interobserver variation and efficacy for determining stage C disease. American Journal of Roentgenology, 158(3), 559-562.

MR imaging in adenocarcinoma of the prostate : Interobserver variation and efficacy for determining stage C disease. / Schiebler, M. L.; Yankaskas, B. C.; Tempany, C.; Spritzer, C. E.; Rifkin, M. D.; Pollack, H. M.; Holtz, P.; Zerhouni, Elias.

In: American Journal of Roentgenology, Vol. 158, No. 3, 1992, p. 559-562.

Research output: Contribution to journalArticle

Schiebler, ML, Yankaskas, BC, Tempany, C, Spritzer, CE, Rifkin, MD, Pollack, HM, Holtz, P & Zerhouni, E 1992, 'MR imaging in adenocarcinoma of the prostate: Interobserver variation and efficacy for determining stage C disease', American Journal of Roentgenology, vol. 158, no. 3, pp. 559-562.
Schiebler ML, Yankaskas BC, Tempany C, Spritzer CE, Rifkin MD, Pollack HM et al. MR imaging in adenocarcinoma of the prostate: Interobserver variation and efficacy for determining stage C disease. American Journal of Roentgenology. 1992;158(3):559-562.
Schiebler, M. L. ; Yankaskas, B. C. ; Tempany, C. ; Spritzer, C. E. ; Rifkin, M. D. ; Pollack, H. M. ; Holtz, P. ; Zerhouni, Elias. / MR imaging in adenocarcinoma of the prostate : Interobserver variation and efficacy for determining stage C disease. In: American Journal of Roentgenology. 1992 ; Vol. 158, No. 3. pp. 559-562.
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AU - Spritzer, C. E.

AU - Rifkin, M. D.

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