MR imaging-guided radiofrequency thermal ablation in the porcine brain at 0.2T

E. M. Merkle, J. R. Shonk, L. Zheng, J. L. Duerk, J. S. Lewin

Research output: Contribution to journalArticle

Abstract

The aim of this study was to test the hypotheses that (a) MR imaging-guided radiofrequency (RF) thermal ablation is safe and feasible in porcine brain using an open C-arm-shaped low-field MR system, and that (b) induced thermal lesion size can be predicted using low-field MR imaging. Magnetic resonance-guided RF ablation was performed in the cerebral frontal lobes of six pigs. An 18-G monopolar RF electrode was inserted into the porcine brain using MR image guidance and RF was then applied for 10 min. After post-procedure imaging (T2-weighted, T1-weighted before and after gadodiamide administration), the pigs were killed and the brains were used for pathologic examination. Successful RF electrode placement was accomplished in all cases without complications; total magnet time ranged from 73 to 189 min. The thermal lesion size varied from 10 to 12 mm perpendicular to the electrode track and was easily visualized on T2-weighted and enhanced T1-weighted images. Enhanced T1-weighted imaging demonstrated the highest brain-to-RF thermal lesion contrast-to-noise ratio with an average of 1.5 ± 1.6. Enhanced T1-weighted imaging never underestimated pathologic lesion diameter with a mean difference of 2.3 ± 1.0 mm and a radiologic/pathologic correlation of 0.69. Magnetic resonance imaging-guided RF thermal ablation is feasible and safe in the porcine brain using an open MR low-field system. Induced thermal lesion size can best be monitored using enhanced T1-weighted images. In the future, RF ablation under low-field MR guidance may offer an alternative treatment option for primary and secondary brain tumors.

Original languageEnglish (US)
Pages (from-to)884-892
Number of pages9
JournalEuropean radiology
Volume11
Issue number5
DOIs
StatePublished - Aug 29 2001

Keywords

  • Brain, thermal ablation
  • Experimental
  • Radiofrequency, MR

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Merkle, E. M., Shonk, J. R., Zheng, L., Duerk, J. L., & Lewin, J. S. (2001). MR imaging-guided radiofrequency thermal ablation in the porcine brain at 0.2T. European radiology, 11(5), 884-892. https://doi.org/10.1007/s003300000626