MR imaging-guided radiofrequency thermal ablation in the porcine brain at 0.2T

E. M. Merkle, J. R. Shonk, L. Zheng, J. L. Duerk, J. S. Lewin

Research output: Contribution to journalArticle

Abstract

The aim of this study was to test the hypotheses that (a) MR imaging-guided radiofrequency (RF) thermal ablation is safe and feasible in porcine brain using an open C-arm-shaped low-field MR system, and that (b) induced thermal lesion size can be predicted using low-field MR imaging. Magnetic resonance-guided RF ablation was performed in the cerebral frontal lobes of six pigs. An 18-G monopolar RF electrode was inserted into the porcine brain using MR image guidance and RF was then applied for 10 min. After post-procedure imaging (T2-weighted, T1-weighted before and after gadodiamide administration), the pigs were killed and the brains were used for pathologic examination. Successful RF electrode placement was accomplished in all cases without complications; total magnet time ranged from 73 to 189 min. The thermal lesion size varied from 10 to 12 mm perpendicular to the electrode track and was easily visualized on T2-weighted and enhanced T1-weighted images. Enhanced T1-weighted imaging demonstrated the highest brain-to-RF thermal lesion contrast-to-noise ratio with an average of 1.5 ± 1.6. Enhanced T1-weighted imaging never underestimated pathologic lesion diameter with a mean difference of 2.3 ± 1.0 mm and a radiologic/pathologic correlation of 0.69. Magnetic resonance imaging-guided RF thermal ablation is feasible and safe in the porcine brain using an open MR low-field system. Induced thermal lesion size can best be monitored using enhanced T1-weighted images. In the future, RF ablation under low-field MR guidance may offer an alternative treatment option for primary and secondary brain tumors.

Original languageEnglish (US)
Pages (from-to)884-892
Number of pages9
JournalEuropean Radiology
Volume11
Issue number5
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Swine
Hot Temperature
Brain
Electrodes
gadodiamide
Magnets
Frontal Lobe
Brain Neoplasms
Noise
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging

Keywords

  • Brain, thermal ablation
  • Experimental
  • Radiofrequency, MR

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Merkle, E. M., Shonk, J. R., Zheng, L., Duerk, J. L., & Lewin, J. S. (2001). MR imaging-guided radiofrequency thermal ablation in the porcine brain at 0.2T. European Radiology, 11(5), 884-892. https://doi.org/10.1007/s003300000626

MR imaging-guided radiofrequency thermal ablation in the porcine brain at 0.2T. / Merkle, E. M.; Shonk, J. R.; Zheng, L.; Duerk, J. L.; Lewin, J. S.

In: European Radiology, Vol. 11, No. 5, 2001, p. 884-892.

Research output: Contribution to journalArticle

Merkle, EM, Shonk, JR, Zheng, L, Duerk, JL & Lewin, JS 2001, 'MR imaging-guided radiofrequency thermal ablation in the porcine brain at 0.2T', European Radiology, vol. 11, no. 5, pp. 884-892. https://doi.org/10.1007/s003300000626
Merkle, E. M. ; Shonk, J. R. ; Zheng, L. ; Duerk, J. L. ; Lewin, J. S. / MR imaging-guided radiofrequency thermal ablation in the porcine brain at 0.2T. In: European Radiology. 2001 ; Vol. 11, No. 5. pp. 884-892.
@article{5c1affc0ff424e99ba1d74b0640c93ba,
title = "MR imaging-guided radiofrequency thermal ablation in the porcine brain at 0.2T",
abstract = "The aim of this study was to test the hypotheses that (a) MR imaging-guided radiofrequency (RF) thermal ablation is safe and feasible in porcine brain using an open C-arm-shaped low-field MR system, and that (b) induced thermal lesion size can be predicted using low-field MR imaging. Magnetic resonance-guided RF ablation was performed in the cerebral frontal lobes of six pigs. An 18-G monopolar RF electrode was inserted into the porcine brain using MR image guidance and RF was then applied for 10 min. After post-procedure imaging (T2-weighted, T1-weighted before and after gadodiamide administration), the pigs were killed and the brains were used for pathologic examination. Successful RF electrode placement was accomplished in all cases without complications; total magnet time ranged from 73 to 189 min. The thermal lesion size varied from 10 to 12 mm perpendicular to the electrode track and was easily visualized on T2-weighted and enhanced T1-weighted images. Enhanced T1-weighted imaging demonstrated the highest brain-to-RF thermal lesion contrast-to-noise ratio with an average of 1.5 ± 1.6. Enhanced T1-weighted imaging never underestimated pathologic lesion diameter with a mean difference of 2.3 ± 1.0 mm and a radiologic/pathologic correlation of 0.69. Magnetic resonance imaging-guided RF thermal ablation is feasible and safe in the porcine brain using an open MR low-field system. Induced thermal lesion size can best be monitored using enhanced T1-weighted images. In the future, RF ablation under low-field MR guidance may offer an alternative treatment option for primary and secondary brain tumors.",
keywords = "Brain, thermal ablation, Experimental, Radiofrequency, MR",
author = "Merkle, {E. M.} and Shonk, {J. R.} and L. Zheng and Duerk, {J. L.} and Lewin, {J. S.}",
year = "2001",
doi = "10.1007/s003300000626",
language = "English (US)",
volume = "11",
pages = "884--892",
journal = "European Radiology",
issn = "0938-7994",
publisher = "Springer Verlag",
number = "5",

}

TY - JOUR

T1 - MR imaging-guided radiofrequency thermal ablation in the porcine brain at 0.2T

AU - Merkle, E. M.

AU - Shonk, J. R.

AU - Zheng, L.

AU - Duerk, J. L.

AU - Lewin, J. S.

PY - 2001

Y1 - 2001

N2 - The aim of this study was to test the hypotheses that (a) MR imaging-guided radiofrequency (RF) thermal ablation is safe and feasible in porcine brain using an open C-arm-shaped low-field MR system, and that (b) induced thermal lesion size can be predicted using low-field MR imaging. Magnetic resonance-guided RF ablation was performed in the cerebral frontal lobes of six pigs. An 18-G monopolar RF electrode was inserted into the porcine brain using MR image guidance and RF was then applied for 10 min. After post-procedure imaging (T2-weighted, T1-weighted before and after gadodiamide administration), the pigs were killed and the brains were used for pathologic examination. Successful RF electrode placement was accomplished in all cases without complications; total magnet time ranged from 73 to 189 min. The thermal lesion size varied from 10 to 12 mm perpendicular to the electrode track and was easily visualized on T2-weighted and enhanced T1-weighted images. Enhanced T1-weighted imaging demonstrated the highest brain-to-RF thermal lesion contrast-to-noise ratio with an average of 1.5 ± 1.6. Enhanced T1-weighted imaging never underestimated pathologic lesion diameter with a mean difference of 2.3 ± 1.0 mm and a radiologic/pathologic correlation of 0.69. Magnetic resonance imaging-guided RF thermal ablation is feasible and safe in the porcine brain using an open MR low-field system. Induced thermal lesion size can best be monitored using enhanced T1-weighted images. In the future, RF ablation under low-field MR guidance may offer an alternative treatment option for primary and secondary brain tumors.

AB - The aim of this study was to test the hypotheses that (a) MR imaging-guided radiofrequency (RF) thermal ablation is safe and feasible in porcine brain using an open C-arm-shaped low-field MR system, and that (b) induced thermal lesion size can be predicted using low-field MR imaging. Magnetic resonance-guided RF ablation was performed in the cerebral frontal lobes of six pigs. An 18-G monopolar RF electrode was inserted into the porcine brain using MR image guidance and RF was then applied for 10 min. After post-procedure imaging (T2-weighted, T1-weighted before and after gadodiamide administration), the pigs were killed and the brains were used for pathologic examination. Successful RF electrode placement was accomplished in all cases without complications; total magnet time ranged from 73 to 189 min. The thermal lesion size varied from 10 to 12 mm perpendicular to the electrode track and was easily visualized on T2-weighted and enhanced T1-weighted images. Enhanced T1-weighted imaging demonstrated the highest brain-to-RF thermal lesion contrast-to-noise ratio with an average of 1.5 ± 1.6. Enhanced T1-weighted imaging never underestimated pathologic lesion diameter with a mean difference of 2.3 ± 1.0 mm and a radiologic/pathologic correlation of 0.69. Magnetic resonance imaging-guided RF thermal ablation is feasible and safe in the porcine brain using an open MR low-field system. Induced thermal lesion size can best be monitored using enhanced T1-weighted images. In the future, RF ablation under low-field MR guidance may offer an alternative treatment option for primary and secondary brain tumors.

KW - Brain, thermal ablation

KW - Experimental

KW - Radiofrequency, MR

UR - http://www.scopus.com/inward/record.url?scp=0034879838&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034879838&partnerID=8YFLogxK

U2 - 10.1007/s003300000626

DO - 10.1007/s003300000626

M3 - Article

C2 - 11372628

AN - SCOPUS:0034879838

VL - 11

SP - 884

EP - 892

JO - European Radiology

JF - European Radiology

SN - 0938-7994

IS - 5

ER -