TY - JOUR
T1 - MR imaging-guided radio-frequency thermal ablation in the pancreas in a porcine model with a modified clinical C-arm system
AU - Merkle, Elmar M.
AU - Haaga, John R.
AU - Duerk, Jeffrey L.
AU - Jacobs, Gretta H.
AU - Brambs, Hans Juergen
AU - Lewin, Jonathan S.
PY - 1999/11
Y1 - 1999/11
N2 - PURPOSE: To test the hypotheses that (a) magnetic resonance (MR) imaging-guided radio-frequency (RF) thermal ablation in the pancreas is safe and feasible in a porcine model and (b) induced thermal lesion size can be predicted with MR imaging monitoring. MATERIALS AND METHODS: MR imaging- guided RF ablation was performed in the pancreas of six pigs. A 17-gauge monopolar RF probe was inserted into the pancreas with MR imaging guidance, and RF was applied for 10 minutes. After postprocedural imaging (T2-weighted, short inversion time inversion-recovery [STIR], and T1-weighted imaging before and after intravenous administration of gadodiamide), the pigs were observed for 7 days and follow-up MR images were acquired. The pigs were sacrificed, and pathologic examination was performed. RESULTS: Successful RF probe placement was accomplished in all pigs; the interventional procedure took 46-80 minutes. Thermal lesions were 12-15 mm perpendicular to the probe track and were best seen on STIR and contrast material-enhanced T1-weighted images with a radiologic and/or pathologic mean difference in RF lesion diameter of 1.7 mm ± 1.0 (SD) and 0.8 mm ± 1.2, respectively. Diarrhea was the only side effect during the 1-week follow-up; no clinical signs of pancreatitis occurred. CONCLUSION: MR imaging-guided RF thermal ablation in the pancreas is feasible and safe. Induced thermal lesion size can best be monitored with STIR and contrast-enhanced T1-weighted images. In the future, RF ablation may offer an alternative treatment option for pancreatic cancer.
AB - PURPOSE: To test the hypotheses that (a) magnetic resonance (MR) imaging-guided radio-frequency (RF) thermal ablation in the pancreas is safe and feasible in a porcine model and (b) induced thermal lesion size can be predicted with MR imaging monitoring. MATERIALS AND METHODS: MR imaging- guided RF ablation was performed in the pancreas of six pigs. A 17-gauge monopolar RF probe was inserted into the pancreas with MR imaging guidance, and RF was applied for 10 minutes. After postprocedural imaging (T2-weighted, short inversion time inversion-recovery [STIR], and T1-weighted imaging before and after intravenous administration of gadodiamide), the pigs were observed for 7 days and follow-up MR images were acquired. The pigs were sacrificed, and pathologic examination was performed. RESULTS: Successful RF probe placement was accomplished in all pigs; the interventional procedure took 46-80 minutes. Thermal lesions were 12-15 mm perpendicular to the probe track and were best seen on STIR and contrast material-enhanced T1-weighted images with a radiologic and/or pathologic mean difference in RF lesion diameter of 1.7 mm ± 1.0 (SD) and 0.8 mm ± 1.2, respectively. Diarrhea was the only side effect during the 1-week follow-up; no clinical signs of pancreatitis occurred. CONCLUSION: MR imaging-guided RF thermal ablation in the pancreas is feasible and safe. Induced thermal lesion size can best be monitored with STIR and contrast-enhanced T1-weighted images. In the future, RF ablation may offer an alternative treatment option for pancreatic cancer.
KW - Interventional procedures, experimental studies
KW - Magnetic resonance (MR), guidance
KW - Pancreas, interventional procedures
KW - Pancreatitis
KW - Radiofrequency (RF) ablation
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U2 - 10.1148/radiology.213.2.r99nv21461
DO - 10.1148/radiology.213.2.r99nv21461
M3 - Article
C2 - 10551227
AN - SCOPUS:0032712796
SN - 0033-8419
VL - 213
SP - 461
EP - 467
JO - RADIOLOGY
JF - RADIOLOGY
IS - 2
ER -