MR imaging-guided radio-frequency thermal ablation in the pancreas in a porcine model with a modified clinical C-arm system

Elmar M. Merkle, John R. Haaga, Jeffrey L. Duerk, Gretta H. Jacobs, Hans Juergen Brambs, Jonathan S. Lewin

Research output: Contribution to journalArticle

Abstract

PURPOSE: To test the hypotheses that (a) magnetic resonance (MR) imaging-guided radio-frequency (RF) thermal ablation in the pancreas is safe and feasible in a porcine model and (b) induced thermal lesion size can be predicted with MR imaging monitoring. MATERIALS AND METHODS: MR imaging- guided RF ablation was performed in the pancreas of six pigs. A 17-gauge monopolar RF probe was inserted into the pancreas with MR imaging guidance, and RF was applied for 10 minutes. After postprocedural imaging (T2-weighted, short inversion time inversion-recovery [STIR], and T1-weighted imaging before and after intravenous administration of gadodiamide), the pigs were observed for 7 days and follow-up MR images were acquired. The pigs were sacrificed, and pathologic examination was performed. RESULTS: Successful RF probe placement was accomplished in all pigs; the interventional procedure took 46-80 minutes. Thermal lesions were 12-15 mm perpendicular to the probe track and were best seen on STIR and contrast material-enhanced T1-weighted images with a radiologic and/or pathologic mean difference in RF lesion diameter of 1.7 mm ± 1.0 (SD) and 0.8 mm ± 1.2, respectively. Diarrhea was the only side effect during the 1-week follow-up; no clinical signs of pancreatitis occurred. CONCLUSION: MR imaging-guided RF thermal ablation in the pancreas is feasible and safe. Induced thermal lesion size can best be monitored with STIR and contrast-enhanced T1-weighted images. In the future, RF ablation may offer an alternative treatment option for pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)461-467
Number of pages7
JournalRadiology
Volume213
Issue number2
StatePublished - Nov 1999
Externally publishedYes

Fingerprint

Radio
Pancreas
Swine
Hot Temperature
Magnetic Resonance Imaging
gadodiamide
Pancreatic Neoplasms
Pancreatitis
Intravenous Administration
Contrast Media
Diarrhea
Magnetic Resonance Spectroscopy

Keywords

  • Interventional procedures, experimental studies
  • Magnetic resonance (MR), guidance
  • Pancreas, interventional procedures
  • Pancreatitis
  • Radiofrequency (RF) ablation

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Merkle, E. M., Haaga, J. R., Duerk, J. L., Jacobs, G. H., Brambs, H. J., & Lewin, J. S. (1999). MR imaging-guided radio-frequency thermal ablation in the pancreas in a porcine model with a modified clinical C-arm system. Radiology, 213(2), 461-467.

MR imaging-guided radio-frequency thermal ablation in the pancreas in a porcine model with a modified clinical C-arm system. / Merkle, Elmar M.; Haaga, John R.; Duerk, Jeffrey L.; Jacobs, Gretta H.; Brambs, Hans Juergen; Lewin, Jonathan S.

In: Radiology, Vol. 213, No. 2, 11.1999, p. 461-467.

Research output: Contribution to journalArticle

Merkle, EM, Haaga, JR, Duerk, JL, Jacobs, GH, Brambs, HJ & Lewin, JS 1999, 'MR imaging-guided radio-frequency thermal ablation in the pancreas in a porcine model with a modified clinical C-arm system', Radiology, vol. 213, no. 2, pp. 461-467.
Merkle EM, Haaga JR, Duerk JL, Jacobs GH, Brambs HJ, Lewin JS. MR imaging-guided radio-frequency thermal ablation in the pancreas in a porcine model with a modified clinical C-arm system. Radiology. 1999 Nov;213(2):461-467.
Merkle, Elmar M. ; Haaga, John R. ; Duerk, Jeffrey L. ; Jacobs, Gretta H. ; Brambs, Hans Juergen ; Lewin, Jonathan S. / MR imaging-guided radio-frequency thermal ablation in the pancreas in a porcine model with a modified clinical C-arm system. In: Radiology. 1999 ; Vol. 213, No. 2. pp. 461-467.
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