MR imaging and the development of stem cell-based therapies

Piotr Walczak, Jeff W Bulte

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Technological advancements in recent years have introduced various in vivo imaging modalities for the study of living organisms, including those suitable for cellular imaging. Positron emission tomography (PET) [1], bioluminescent imaging [2], single photon emission tomography (SPECT) [3], and MRI [4] are all suitable to track labeled cells, with MRI having superior temporal and spatial resolution. Tracking cells using MRI relies on biocompatible MR contrast agents allowing repetitive monitoring of targeted cells. The rapidly growing stem cell field has recognized in vivo cell visualization as a valuable tool to study the biology of stem cells, as well as a noninvasive method for in vivo monitoring, which may also facilitate proper translation of stem cell-based therapies into the clinical setting. Stem cell therapy is currently being evaluated as a possible treatment for numerous diseases, with an emphasis on brain or cardiac disorders for which an effective therapy is lacking.

Original languageEnglish (US)
Title of host publicationIn Vivo MR Techniques in Drug Discovery and Development
PublisherCRC Press
Pages511-535
Number of pages25
ISBN (Electronic)9781420004526
ISBN (Print)9780849330261
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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