Abstract
Technological advancements in recent years have introduced various in vivo imaging modalities for the study of living organisms, including those suitable for cellular imaging. Positron emission tomography (PET) [1], bioluminescent imaging [2], single photon emission tomography (SPECT) [3], and MRI [4] are all suitable to track labeled cells, with MRI having superior temporal and spatial resolution. Tracking cells using MRI relies on biocompatible MR contrast agents allowing repetitive monitoring of targeted cells. The rapidly growing stem cell field has recognized in vivo cell visualization as a valuable tool to study the biology of stem cells, as well as a noninvasive method for in vivo monitoring, which may also facilitate proper translation of stem cell-based therapies into the clinical setting. Stem cell therapy is currently being evaluated as a possible treatment for numerous diseases, with an emphasis on brain or cardiac disorders for which an effective therapy is lacking.
| Original language | English (US) |
|---|---|
| Title of host publication | In Vivo MR Techniques in Drug Discovery and Development |
| Publisher | CRC Press |
| Pages | 511-535 |
| Number of pages | 25 |
| ISBN (Electronic) | 9781420004526 |
| ISBN (Print) | 9780849330261 |
| State | Published - Jan 1 2006 |
ASJC Scopus subject areas
- Medicine(all)
- Pharmacology, Toxicology and Pharmaceutics(all)