MR image-guided endovascular procedures with the ultrasmall superparamagnetic iron oxide SH U 555 C as an intravascular contrast agent: Study in pigs

Frank K. Wacker, Klaus Reither, Wolfgang Ebert, Michael Wendt, Jonathan S. Lewin, Karl Juergen Wolf

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: To evaluate the feasibility of using the ultrasmall superparamagnetic iron oxide (USPIO) SH U 555 C as an intravascular contrast agent for magnetic resonance (MR) image-guided vascular procedures with an open MR imaging system. MATERIALS AND METHODS: All experiments were performed with MR imaging at 0.2 T. MR image-guided interventions were performed in USPIO-enhanced vessels in four pigs. With near real-time MR image guidance (acquisition time, 0.64 second per section), the splenic and renal arteries were consecutively catheterized by using a susceptibility artifact-based catheter-guide wire combination. Angioplasty and stent implantation were performed four times in the renal artery and twice in the iliac artery. Intraaortal signal intensity (SI) was measured during the interventions. RESULTS: After administration of SH U 555 C (40 μmol of iron per kilogram of body weight), a three-dimensional MR angiographic sequence was performed that allowed visualization of the abdominal and pelvic vessels that were as small as 2 mm in diameter. Catheterization, angioplasty, and stent implantation were successfully guided in the USPIO-enhanced vasculature. Sixty minutes after contrast agent injection, the mean aortic SI was 70% of the maximum measured enhancement levels. CONCLUSION: One intravenous injection of SH U 555 C enabled long, continuous intravascular SI enhancement at MR angiography, and, in combination with susceptibility artifact-based device tracking, the injection allowed the performance of MR imaging-guided intravascular interventions in an open MR imaging system.

Original languageEnglish (US)
Pages (from-to)459-464
Number of pages6
JournalRADIOLOGY
Volume226
Issue number2
DOIs
StatePublished - Feb 1 2003

Keywords

  • Animals
  • Interventional procedures, experimental studies
  • Magnetic resonance (MR), contrast, media
  • Magnetic resonance (MR), vascular studies
  • Stents and prostheses

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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