MR-guided portal vein delivery and monitoring of magnetocapsules: Assessment of physiologic effects on the liver

Thomas W. Link, David Woodrum, Wesley D. Gilson, Li Pan, Di Qian, Dara L. Kraitchman, Jeff W.M. Bulte, Aravind Arepally, Clifford R. Weiss

Research output: Contribution to journalArticle

Abstract

Purpose: The authors previously developed magnetic resonance (MR)trackable magnetocapsules (MCs) that can simultaneously immunoprotect human islet cells and noninvasively monitor portal delivery and engraftment in real time with MR imaging. This study was designed to assess the physiologic effects of the delivery of a clinical dose of MCs (140,000 capsules) into the portal vein (PV) in swine over a 1-month period. Materials and Methods: MCs were formed by using clinical-grade alginate mixed with a clinically applicable dosage of ferumoxide. Percutaneous access into the PV was obtained by using a custom-built, MR-trackable needle, and 140,000 MCs were delivered under MR guidance in five swine. Portal pressures and liver function data were obtained over a 4-week period. Results: A transient increase in portal pressure occurred immediately after MC delivery that returned to normal levels by 4 weeks after MC delivery. Liver function test results were normal during the entire period, and the appearance of the MCs on MR imaging did not change. Conclusions: A clinically applicable dose of 140,000 MCs has no adverse effects on portal pressures or liver function in this normal swine model during the first month after delivery.

Original languageEnglish (US)
Pages (from-to)1335-1340
Number of pages6
JournalJournal of Vascular and Interventional Radiology
Volume22
Issue number9
DOIs
StatePublished - Sep 1 2011

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Keywords

  • MC
  • PV
  • magnetocapsule
  • portal vein

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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