MR-guided catheter-based excitation emission optical spectroscopy for in vivo tissue characterization

D. A. Herzka, M. S. Kotys, S. Krueger, B. J. Traughber, J. Heroux, A. M. Gharib, J. Ohayon, S. Weiss, R. I. Pettigrew, B. J. Wood

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Excitation emission spectroscopy (EES) has been used in the past to characterize many different types of tissue. This technique uses multiple excitation wavelengths and samples a complete optical spectrum for each, yielding an excitation-emission matrix (EEM). Upon study of the EEM, it is possible to determine the presence of multiple optical contrast agents since these dyes can have characteristic spectra that can be separated. Here, we demonstrate EES specifically designed for use in conjunction with MR. This EES is applied with an in-suite control setup that permits real-time navigation, utilizing active MR tracking catheters, and providing a platform for MR-guided tissue characterization. The EES system is used in a demonstration experiment to highlight MR imaging, MR guidance in conjunction with a catheter-based optical measurement.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2008 - Visualization, Image-Guided Procedures, and Modeling
DOIs
StatePublished - Jun 18 2008
EventMedical Imaging 2008 - Visualization, Image-Guided Procedures, and Modeling - San Diego, CA, United States
Duration: Feb 17 2008Feb 19 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6918
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2008 - Visualization, Image-Guided Procedures, and Modeling
CountryUnited States
CitySan Diego, CA
Period2/17/082/19/08

Keywords

  • Excitation-emission spectroscopy
  • In vivo tissue characterization
  • MR guidance
  • MR-guided tissue characterization
  • Tissue characterization

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Herzka, D. A., Kotys, M. S., Krueger, S., Traughber, B. J., Heroux, J., Gharib, A. M., Ohayon, J., Weiss, S., Pettigrew, R. I., & Wood, B. J. (2008). MR-guided catheter-based excitation emission optical spectroscopy for in vivo tissue characterization. In Medical Imaging 2008 - Visualization, Image-Guided Procedures, and Modeling [69181U] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6918). https://doi.org/10.1117/12.770758