Mr color mapping of myelin fiber orientation

Philippe Douek, Robert Turner, James J Pekar, Nicholas Patronas, Denis Le Bihan

Research output: Contribution to journalArticle

Abstract

Diffusion of water in brain white matter has been shown to be anisotropic: Water mobility is lower when measured perpendicular to the fiber direction rather than parallel to it. This feature was used to produce images of the myelin fiber orientation. Coronal and sagittal MR diffusion images were obtained in volunteers using an echo-planar imaging sequence sensitized to molecular diffusion in perpendicular directions. Color-coded images of myelin orientation were then generated by combining these images together. The orientation of the white matter tracts was found to be in excellent agreement with known anatomy. Myelin fiber orientation mapping may offer a new perspective to evaluate white matter disorders.

Original languageEnglish (US)
Pages (from-to)923-929
Number of pages7
JournalJournal of Computer Assisted Tomography
Volume15
Issue number6
StatePublished - 1991
Externally publishedYes

Fingerprint

Myelin Sheath
Color
Echo-Planar Imaging
Water
Volunteers
Anatomy
Brain
White Matter
Direction compound

Keywords

  • Brain
  • Diseases
  • Magnetic resonance imaging techniques
  • Myelin

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Douek, P., Turner, R., Pekar, J. J., Patronas, N., & Le Bihan, D. (1991). Mr color mapping of myelin fiber orientation. Journal of Computer Assisted Tomography, 15(6), 923-929.

Mr color mapping of myelin fiber orientation. / Douek, Philippe; Turner, Robert; Pekar, James J; Patronas, Nicholas; Le Bihan, Denis.

In: Journal of Computer Assisted Tomography, Vol. 15, No. 6, 1991, p. 923-929.

Research output: Contribution to journalArticle

Douek, P, Turner, R, Pekar, JJ, Patronas, N & Le Bihan, D 1991, 'Mr color mapping of myelin fiber orientation', Journal of Computer Assisted Tomography, vol. 15, no. 6, pp. 923-929.
Douek P, Turner R, Pekar JJ, Patronas N, Le Bihan D. Mr color mapping of myelin fiber orientation. Journal of Computer Assisted Tomography. 1991;15(6):923-929.
Douek, Philippe ; Turner, Robert ; Pekar, James J ; Patronas, Nicholas ; Le Bihan, Denis. / Mr color mapping of myelin fiber orientation. In: Journal of Computer Assisted Tomography. 1991 ; Vol. 15, No. 6. pp. 923-929.
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