MR-based statistical atlas of the Göttingen minipig brain

Hideaki Watanabe, Flemming Andersen, Claus Z. Simonsen, Stephen M. Evans, Albert Gjedde, Paul Cumming

Research output: Contribution to journalArticle

Abstract

The domestic pig is increasingly being used as an experimental model for brain imaging studies with positron emission tomography (PET). The recording of radiotracer uptake by PET gives functional and physiological information, but with poor spatial resolution. To date, anatomical regions of interest in pig brain have been defined in MR images obtained for each individual animal, because of the lack of a standard stereotaxic coordinate system for the pig brain. In order to define a stereotaxic coordinate system, we coregistered T1-weighted MR images from 22 male Göttingen minipigs and obtained a statistically defined surface rendering of the average minipig brain in which stereotaxic zero is defined by the position of the pineal gland. The average brain is now used as a target for registration of dynamic PET data, so that time-activity curves can be extracted from standard volumes of interest. In order to define these volumes, MR images from each individual pig were manually segmented into a total of 34 brain structures, including cortical regions, white matter, caudate and putamen, ventricular system, and cerebellum. The mean volumes of these structures had variances in the range of 10-20%. The 34 brain volumes were transformed into the common coordinate system and then used to generate surface renderings with probabilistic threshold greater than 50%. This probabilistic threshold gave nearly quantitative recovery of the mean volumes in native space. The probabilistic volumes in stereotaxic space are now being used to extract time-radioactivity curves from dynamic PET recordings.

Original languageEnglish (US)
Pages (from-to)1089-1096
Number of pages8
JournalNeuroImage
Volume14
Issue number5
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Miniature Swine
Atlases
Positron-Emission Tomography
Brain
Swine
Sus scrofa
Pineal Gland
Putamen
Neuroimaging
Cerebellum
Radioactivity
Theoretical Models

Keywords

  • Anatomy
  • Brain volumes
  • Göttingen minipig
  • MRI-PET coregistration
  • Segmentation

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Watanabe, H., Andersen, F., Simonsen, C. Z., Evans, S. M., Gjedde, A., & Cumming, P. (2001). MR-based statistical atlas of the Göttingen minipig brain. NeuroImage, 14(5), 1089-1096. https://doi.org/10.1006/nimg.2001.0910

MR-based statistical atlas of the Göttingen minipig brain. / Watanabe, Hideaki; Andersen, Flemming; Simonsen, Claus Z.; Evans, Stephen M.; Gjedde, Albert; Cumming, Paul.

In: NeuroImage, Vol. 14, No. 5, 2001, p. 1089-1096.

Research output: Contribution to journalArticle

Watanabe, H, Andersen, F, Simonsen, CZ, Evans, SM, Gjedde, A & Cumming, P 2001, 'MR-based statistical atlas of the Göttingen minipig brain', NeuroImage, vol. 14, no. 5, pp. 1089-1096. https://doi.org/10.1006/nimg.2001.0910
Watanabe H, Andersen F, Simonsen CZ, Evans SM, Gjedde A, Cumming P. MR-based statistical atlas of the Göttingen minipig brain. NeuroImage. 2001;14(5):1089-1096. https://doi.org/10.1006/nimg.2001.0910
Watanabe, Hideaki ; Andersen, Flemming ; Simonsen, Claus Z. ; Evans, Stephen M. ; Gjedde, Albert ; Cumming, Paul. / MR-based statistical atlas of the Göttingen minipig brain. In: NeuroImage. 2001 ; Vol. 14, No. 5. pp. 1089-1096.
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