MPEx: A tool for exploring membrane proteins

Craig Snider; Sajith Jayasinghe; Kalina Hristova; Stephen H. White

doi:10.1002/pro.256

MPEx: A tool for exploring membrane proteins

Craig Snider, Sajith Jayasinghe, Kalina Hristova, Stephen H. White

Whiting School of Engineering

Research output: Contribution to journal › Article › peer-review

178 Scopus citations

Abstract

Hydropathy plot methods form a cornerstone of membrane protein research, especially in the early stages of biochemical and structural characterization. Membrane Protein Explorer (MPEx), described in this article, is a refined and versatile hydropathy-plot software tool for analyzing membrane protein sequences. MPEx is highly interactive and facilitates the characterization and identification of favorable protein transmembrane regions using experimentbased physical and biological hydrophobicity scales. Besides allowing the consequences of sequence mutations to be examined, it provides tools for aiding the design of membrane-active peptides. MPEx is freely available as a Java Web Start application from our web site at http://blanco.biomol.uci.edu/mpex. Published by Wiley-Blackwell.

Original language	English (US)
Pages (from-to)	2624-2628
Number of pages	5
Journal	Protein Science
Volume	18
Issue number	12
DOIs	https://doi.org/10.1002/pro.256
State	Published - Dec 2009

Keywords

Hydropathy plots
Hydrophobicity
Membrane protein explorer
Structure prediction
Topology
Transmembrane helices

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1002/pro.256

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abstract = "Hydropathy plot methods form a cornerstone of membrane protein research, especially in the early stages of biochemical and structural characterization. Membrane Protein Explorer (MPEx), described in this article, is a refined and versatile hydropathy-plot software tool for analyzing membrane protein sequences. MPEx is highly interactive and facilitates the characterization and identification of favorable protein transmembrane regions using experimentbased physical and biological hydrophobicity scales. Besides allowing the consequences of sequence mutations to be examined, it provides tools for aiding the design of membrane-active peptides. MPEx is freely available as a Java Web Start application from our web site at http://blanco.biomol.uci.edu/mpex. Published by Wiley-Blackwell.",

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AU - Hristova, Kalina

AU - White, Stephen H.

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AB - Hydropathy plot methods form a cornerstone of membrane protein research, especially in the early stages of biochemical and structural characterization. Membrane Protein Explorer (MPEx), described in this article, is a refined and versatile hydropathy-plot software tool for analyzing membrane protein sequences. MPEx is highly interactive and facilitates the characterization and identification of favorable protein transmembrane regions using experimentbased physical and biological hydrophobicity scales. Besides allowing the consequences of sequence mutations to be examined, it provides tools for aiding the design of membrane-active peptides. MPEx is freely available as a Java Web Start application from our web site at http://blanco.biomol.uci.edu/mpex. Published by Wiley-Blackwell.

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KW - Membrane protein explorer

KW - Structure prediction

KW - Topology

KW - Transmembrane helices

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MPEx: A tool for exploring membrane proteins

Abstract

Keywords

ASJC Scopus subject areas

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