MPEx: A tool for exploring membrane proteins

Craig Snider, Sajith Jayasinghe, Kalina Hristova, Stephen H. White

Research output: Contribution to journalArticlepeer-review

Abstract

Hydropathy plot methods form a cornerstone of membrane protein research, especially in the early stages of biochemical and structural characterization. Membrane Protein Explorer (MPEx), described in this article, is a refined and versatile hydropathy-plot software tool for analyzing membrane protein sequences. MPEx is highly interactive and facilitates the characterization and identification of favorable protein transmembrane regions using experimentbased physical and biological hydrophobicity scales. Besides allowing the consequences of sequence mutations to be examined, it provides tools for aiding the design of membrane-active peptides. MPEx is freely available as a Java Web Start application from our web site at http://blanco.biomol.uci.edu/mpex. Published by Wiley-Blackwell.

Original languageEnglish (US)
Pages (from-to)2624-2628
Number of pages5
JournalProtein Science
Volume18
Issue number12
DOIs
StatePublished - Dec 2009

Keywords

  • Hydropathy plots
  • Hydrophobicity
  • Membrane protein explorer
  • Structure prediction
  • Topology
  • Transmembrane helices

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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