Moxifloxacin-containing regimens of reduced duration produce a stable cure in murine tuberculosis

Eric L. Nuermberger, Tetsuyuki Yoshimatsu, Sandeep Tyagi, Kathy Williams, Ian Rosenthal, Richard J. O'Brien, Andrew A. Vernon, Richard E. Chaisson, William R. Bishai, Jacques H. Grosset

Research output: Contribution to journalArticle

Abstract

In a recent experimental study using the mouse model of tuberculosis, treatment with a combination of rifampin, moxifloxacin, and pyrazinamide was able to shorten the time to negative lung cultures by up to 2 months compared with the standard regimen of rifampin, isoniazid, and pyrazinamide. To confirm that this substitution of moxifloxacin for isoniazid permits a shorter duration of treatment, a second study was performed in which mice were assessed for relapse after treatment with combination therapy for 3, 4, 5, or 6 months. Although no relapse was observed among mice treated for at least 4 months with rifampin, moxifloxacin, and pyrazinamide, mice treated with rifampin, isoniazid, and pyrazinamide required 6 months of treatment before no relapse could be detected. For mice treated with rifampin, moxifloxacin, and pyrazinamide, similar efficacy was noted whether pyrazinamide was administered for 1 month, 2 months, or the entire duration of therapy. These results suggest that the use of rifampin, moxifloxacin, and pyrazinamide may substantially shorten the duration of therapy needed to cure human tuberculosis and that the full benefit of pyrazinamide in this regimen may be realized after just 1 month of treatment.

Original languageEnglish (US)
Pages (from-to)1131-1134
Number of pages4
JournalAmerican journal of respiratory and critical care medicine
Volume170
Issue number10
DOIs
StatePublished - Nov 15 2004

Keywords

  • Fluoroquinolone
  • Mouse
  • Moxifloxacin
  • Pyrazinamide
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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