Moxalactam-tobramycin-resistant Pseudomonas aeruginosa Isolates in Patients with Cystic Fibrosis

Sherahe Brown Fitzpatrick, Beryl J. Rosenstein

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In vitro studies have shown synergistic killing activity against Pseudomonas aeruginosa (PA) with the combination of an aminoglycoside and moxalactam, a new beta-lactam agent. We describe three patients with cystic fibrosis (CF) with PA isolates that were resistant to all single-agent antibiotics, but sensitive to the combination of moxalactam-tobramycin. Initially, all patients had a good clinical response to this combination. However, during a second course of therapy, there was clinical deterioration coincident with the rapid emergence of moxalactam-tobramycin-resistant PA isolates.

Original languageEnglish (US)
Pages (from-to)628-630
Number of pages3
JournalClinical pediatrics
Issue number9
StatePublished - Sep 1983


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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