Moving towards a paradigm

common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes.

Yulia Artemenko, Thomas J. Lampert, Peter N Devreotes

Research output: Contribution to journalArticle

Abstract

Chemotaxis, or directed migration of cells along a chemical gradient, is a highly coordinated process that involves gradient sensing, motility, and polarity. Most of our understanding of chemotaxis comes from studies of cells undergoing amoeboid-type migration, in particular the social amoeba Dictyostelium discoideum and leukocytes. In these amoeboid cells the molecular events leading to directed migration can be conceptually divided into four interacting networks: receptor/G protein, signal transduction, cytoskeleton, and polarity. The signal transduction network occupies a central position in this scheme as it receives direct input from the receptor/G protein network, as well as feedback from the cytoskeletal and polarity networks. Multiple overlapping modules within the signal transduction network transmit the signals to the actin cytoskeleton network leading to biased pseudopod protrusion in the direction of the gradient. The overall architecture of the networks, as well as the individual signaling modules, is remarkably conserved between Dictyostelium and mammalian leukocytes, and the similarities and differences between the two systems are the subject of this review.

Original languageEnglish (US)
Pages (from-to)3711-3747
Number of pages37
JournalCellular and Molecular Life Sciences
Volume71
Issue number19
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Dictyostelium
Signal Transduction
Leukocytes
Chemotaxis
GTP-Binding Proteins
Pseudopodia
Amoeba
Cytoskeleton
Actin Cytoskeleton
Cell Movement

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Moving towards a paradigm : common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes. / Artemenko, Yulia; Lampert, Thomas J.; Devreotes, Peter N.

In: Cellular and Molecular Life Sciences, Vol. 71, No. 19, 2014, p. 3711-3747.

Research output: Contribution to journalArticle

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