Moving in the right direction: How eukaryotic cells migrate along chemical gradients

Huaqing Cai, Peter N. Devreotes

Research output: Contribution to journalReview articlepeer-review

Abstract

Many cells have the ability to grow or migrate towards chemical cues. Oriented growth and movement require detection of the external chemical gradient, transduction of signals, and reorganization of the cytoskeleton. Recent studies in Dictyostelium discoideum and mammalian neutrophils have revealed a complex signaling network that enables cells to migrate in chemical gradients.

Original languageEnglish (US)
Pages (from-to)834-841
Number of pages8
JournalSeminars in Cell and Developmental Biology
Volume22
Issue number8
DOIs
StatePublished - Oct 2011

Keywords

  • Chemotaxis
  • Dictyostelium
  • LEGI
  • Neutrophils
  • PI3K
  • PTEN
  • TORC2

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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