@article{caed2160b810421b80cff3b77610b139,
title = "Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary",
abstract = "Frailty has long been an important concept in the practice of geriatric medicine and in gerontological research, but integration and implementation of frailty concepts into clinical practice in the United States has been slow. The National Institute on Aging (NIA) Intramural Research Program and the Johns Hopkins Older Americans Independence Center sponsored a symposium to identify potential barriers that impede the movement of frailty into clinical practice and to highlight opportunities to facilitate the further integration of frailty into clinical practice. Primary and subspecialty care providers, and investigators working to integrate and translate new biological aging knowledge into more specific preventive and treatment strategies for frailty provided the meeting content. Recommendations included a call for more specific language that clarifies conceptual differences between frailty definitions and measurement tools; the development of randomized controlled trials to test whether specific intervention strategies for a variety of conditions differently affect frail and non-frail individuals; development of implementation studies and therapeutic trials aimed at tailoring care as a function of pragmatic frailty markers; the use of deep learning and dynamic systems approaches to improve the translatability of findings from epidemiological studies; and the incorporation of advances in aging biology, especially focused on mitochondria, stem cells, and senescent cells, toward the further development of biologically targeted intervention and prevention strategies that can be used to treat or prevent frailty. J Am Geriatr Soc 67:1559–1564, 2019.",
keywords = "clinical practice, frailty, geroscience",
author = "Jeremy Walston and Karen Bandeen-Roche and Brian Buta and Howard Bergman and Gill, {Thomas M.} and Morley, {John E.} and Fried, {Linda P.} and Robinson, {Thomas N.} and Jonathan Afilalo and Newman, {Anne B.} and Carlos L{\'o}pez-Ot{\'i}n and {De Cabo}, Rafa and Olga Theou and Stephanie Studenski and Cohen, {Harvey J.} and Luigi Ferrucci",
note = "Funding Information: The symposium was supported in part by the Intramural Research Program of the National Institute on Aging [NIA], National Institutes of Health, Baltimore, Maryland, and in part by the Johns Hopkins University Older American Independence Center (NIA Grant P30AG021334). Thomas M. Gill is supported by an NIA Academic Leadership Award (K07AG043587) and the Yale Older Americans Independence Center (NIA P30AG21342). Funding Information: The symposium was supported in part by the Intramural Research Program of the National Institute on Aging [NIA], National Institutes of Health, Baltimore, Maryland, and in part by the Johns Hopkins University Older American Independence Center (NIA Grant P30AG021334). Thomas M. Gill is supported by an NIA Academic Leadership Award (K07AG043587) and the Yale Older Americans Independence Center (NIA P30AG21342). Conflicts of Interest: Linda Fried is a consultant for the scientific advisory board at Biophysics. Stephanie Studinski is a consultant to Merck and Biophytis. She receives royalties from McGraw-Hill and from the University of Kansas for copyrighted work on stroke recovery. Author Contributions: Each author contributed substantively to the conceptualization and preparation of the manuscript. Sponsor's Role: The extramural branch of the National Institute on Aging and the Johns Hopkins Older American Independence Center jointly sponsored the symposium that led to the development of this article. Publisher Copyright: {\textcopyright} 2019 The American Geriatrics Society",
year = "2019",
doi = "10.1111/jgs.15928",
language = "English (US)",
volume = "67",
pages = "1559--1564",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "8",
}