Abstract
Background: Human Siglec-1 mediates HIV trans-infection by interaction with virion-associated sialylated gangliosides. Results: Here, Siglec-1 on mouse macrophages mediated trans-infection of surface-bound MLV. This could be inhibited by biosynthetic modification of sialic acids' N-acyl side chain in virus-producer cells. Conclusion: The N-acyl side chain is a critical determinant of Siglec-1-dependent MLV trans-infection. Significance: Glycoengineering allows manipulation of sialic acid-dependent virus/receptor interactions.
Original language | English (US) |
---|---|
Pages (from-to) | 27345-27359 |
Number of pages | 15 |
Journal | Journal of Biological Chemistry |
Volume | 290 |
Issue number | 45 |
DOIs | |
State | Published - Nov 6 2015 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology