Mouse siglec-1 mediates trans-infection of surface-bound murine leukemia virus in a sialic acid N-acyl side chain-dependent manner

Elina Erikson, Paul R. Wratil, Martin Frank, Ina Ambiel, Katharina Pahnke, Maria Pino, Parastoo Azadi, Nuria Izquierdo-Useros, Javier Martinez-Picado, Chris Meier, Ronald Lee Schnaar, Paul R. Crocker, Werner Reutter, Oliver T. Keppler

Research output: Contribution to journalArticle

Abstract

Background: Human Siglec-1 mediates HIV trans-infection by interaction with virion-associated sialylated gangliosides. Results: Here, Siglec-1 on mouse macrophages mediated trans-infection of surface-bound MLV. This could be inhibited by biosynthetic modification of sialic acids' N-acyl side chain in virus-producer cells. Conclusion: The N-acyl side chain is a critical determinant of Siglec-1-dependent MLV trans-infection. Significance: Glycoengineering allows manipulation of sialic acid-dependent virus/receptor interactions.

Original languageEnglish (US)
Pages (from-to)27345-27359
Number of pages15
JournalJournal of Biological Chemistry
Volume290
Issue number45
DOIs
StatePublished - Nov 6 2015

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Sialic Acid Binding Ig-like Lectin 1
Murine Leukemia Viruses
N-Acetylneuraminic Acid
Viruses
Infection
Sialic Acids
Virus Receptors
Gangliosides
Macrophages
Virion
HIV Infections

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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Mouse siglec-1 mediates trans-infection of surface-bound murine leukemia virus in a sialic acid N-acyl side chain-dependent manner. / Erikson, Elina; Wratil, Paul R.; Frank, Martin; Ambiel, Ina; Pahnke, Katharina; Pino, Maria; Azadi, Parastoo; Izquierdo-Useros, Nuria; Martinez-Picado, Javier; Meier, Chris; Schnaar, Ronald Lee; Crocker, Paul R.; Reutter, Werner; Keppler, Oliver T.

In: Journal of Biological Chemistry, Vol. 290, No. 45, 06.11.2015, p. 27345-27359.

Research output: Contribution to journalArticle

Erikson, E, Wratil, PR, Frank, M, Ambiel, I, Pahnke, K, Pino, M, Azadi, P, Izquierdo-Useros, N, Martinez-Picado, J, Meier, C, Schnaar, RL, Crocker, PR, Reutter, W & Keppler, OT 2015, 'Mouse siglec-1 mediates trans-infection of surface-bound murine leukemia virus in a sialic acid N-acyl side chain-dependent manner', Journal of Biological Chemistry, vol. 290, no. 45, pp. 27345-27359. https://doi.org/10.1074/jbc.M115.681338
Erikson, Elina ; Wratil, Paul R. ; Frank, Martin ; Ambiel, Ina ; Pahnke, Katharina ; Pino, Maria ; Azadi, Parastoo ; Izquierdo-Useros, Nuria ; Martinez-Picado, Javier ; Meier, Chris ; Schnaar, Ronald Lee ; Crocker, Paul R. ; Reutter, Werner ; Keppler, Oliver T. / Mouse siglec-1 mediates trans-infection of surface-bound murine leukemia virus in a sialic acid N-acyl side chain-dependent manner. In: Journal of Biological Chemistry. 2015 ; Vol. 290, No. 45. pp. 27345-27359.
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