Mouse siglec-1 mediates trans-infection of surface-bound murine leukemia virus in a sialic acid N-acyl side chain-dependent manner

Elina Erikson, Paul R. Wratil, Martin Frank, Ina Ambiel, Katharina Pahnke, Maria Pino, Parastoo Azadi, Nuria Izquierdo-Useros, Javier Martinez-Picado, Chris Meier, Ronald L. Schnaar, Paul R. Crocker, Werner Reutter, Oliver T. Keppler

Research output: Contribution to journalArticle

Abstract

Background: Human Siglec-1 mediates HIV trans-infection by interaction with virion-associated sialylated gangliosides. Results: Here, Siglec-1 on mouse macrophages mediated trans-infection of surface-bound MLV. This could be inhibited by biosynthetic modification of sialic acids' N-acyl side chain in virus-producer cells. Conclusion: The N-acyl side chain is a critical determinant of Siglec-1-dependent MLV trans-infection. Significance: Glycoengineering allows manipulation of sialic acid-dependent virus/receptor interactions.

Original languageEnglish (US)
Pages (from-to)27345-27359
Number of pages15
JournalJournal of Biological Chemistry
Volume290
Issue number45
DOIs
StatePublished - Nov 6 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Erikson, E., Wratil, P. R., Frank, M., Ambiel, I., Pahnke, K., Pino, M., Azadi, P., Izquierdo-Useros, N., Martinez-Picado, J., Meier, C., Schnaar, R. L., Crocker, P. R., Reutter, W., & Keppler, O. T. (2015). Mouse siglec-1 mediates trans-infection of surface-bound murine leukemia virus in a sialic acid N-acyl side chain-dependent manner. Journal of Biological Chemistry, 290(45), 27345-27359. https://doi.org/10.1074/jbc.M115.681338